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Malnutrition and vaccination in developing countries

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2015-06, Vol.370 (1671), p.20140141-20140141 [Peer Reviewed Journal]

2015 The Author(s) Published by the Royal Society. All rights reserved. ;2015 The Author(s) Published by the Royal Society. All rights reserved. 2015 ;ISSN: 0962-8436 ;EISSN: 1471-2970 ;DOI: 10.1098/rstb.2014.0141 ;PMID: 25964453

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  • Title:
    Malnutrition and vaccination in developing countries
  • Author: Prendergast, Andrew J.
  • Subjects: Child, Preschool ; Children ; Developing Countries ; Humans ; Immunology ; Infant ; Malnutrition ; Malnutrition - immunology ; Review ; Vaccination
  • Is Part Of: Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2015-06, Vol.370 (1671), p.20140141-20140141
  • Description: Malnutrition contributes to an estimated 45% of deaths among children under 5 years of age in developing countries, predominantly due to infections. Malnourished children therefore stand to benefit hugely from vaccination, but malnutrition has been described as the most common immunodeficiency globally, suggesting that they may not be able to respond effectively to vaccines. The immunology of malnutrition remains poorly characterized, but is associated with impairments in mucosal barrier integrity, and innate and adaptive immune dysfunction. Despite this, the majority of malnourished children can mount a protective immune response following vaccination, although the timing, quality and duration of responses may be impaired. This paper reviews the evidence for vaccine immunogenicity in malnourished children, discusses the importance of vaccination in prevention of malnutrition and highlights evidence gaps in our current knowledge.
  • Publisher: England: The Royal Society
  • Language: English
  • Identifier: ISSN: 0962-8436
    EISSN: 1471-2970
    DOI: 10.1098/rstb.2014.0141
    PMID: 25964453
  • Source: GFMER Free Medical Journals
    MEDLINE
    PubMed Central
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