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Genome editing at the crossroads of delivery, specificity, and fidelity

Trends in biotechnology (Regular ed.), 2015-05, Vol.33 (5), p.280-291 [Peer Reviewed Journal]

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Title:
Genome editing at the crossroads of delivery, specificity, and fidelity
Author: Maggio, Ignazio ; Gonçalves, Manuel A.F.V
Subjects: Animals ; Cell cycle ; Chromosomes ; Cytotoxicity ; delivery systems ; Deoxyribonucleases - chemistry ; Deoxyribonucleases - genetics ; Deoxyribonucleases - physiology ; Deoxyribonucleic acid ; designer nucleases ; DNA ; DNA - chemistry ; DNA repair ; donor DNA ; Efficiency ; Gene Targeting ; Genes ; Genetic engineering ; Genetic Engineering - methods ; Genetic Engineering - standards ; Genetic Engineering - trends ; genome editing ; Genomes ; Genomics ; high fidelity ; Humans ; Internal Medicine ; Models, Genetic ; Mutagenesis ; Mutation ; Protein Engineering ; Proteins
Is Part Of: Trends in biotechnology (Regular ed.), 2015-05, Vol.33 (5), p.280-291
Description: Highlights • The development of genome editing is framed by earlier DNA-modifying technologies. • The various aspects underlying genome editing are reviewed and integrated. • The main genome editing approaches and their collateral effects are discussed. • The efforts seeking improved genome editing end-points are highlighted.
Publisher: England: Elsevier Ltd
Language: English
Identifier: ISSN: 0167-7799
EISSN: 1879-3096
DOI: 10.1016/j.tibtech.2015.02.011
PMID: 25819765
Source: MEDLINE
ProQuest Central

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