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Continuous requirement for the TCR in regulatory T cell function

Nature immunology, 2014-11, Vol.15 (11), p.1070-1078 [Peer Reviewed Journal]

COPYRIGHT 2014 Nature Publishing Group ;COPYRIGHT 2014 Nature Publishing Group ;Copyright Nature Publishing Group Nov 2014 ;ISSN: 1529-2908 ;EISSN: 1529-2916 ;DOI: 10.1038/ni.3004 ;PMID: 25263123

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Title:
Continuous requirement for the TCR in regulatory T cell function
Author: Levine, Andrew G ; Arvey, Aaron ; Jin, Wei ; Rudensky, Alexander Y
Subjects: Animals ; Autoimmunity - immunology ; Cell Adhesion - immunology ; Cell Differentiation - immunology ; Cell receptors ; Diphtheria Toxin - administration & dosage ; Female ; Forkhead Transcription Factors - biosynthesis ; Forkhead Transcription Factors - immunology ; Hyaluronan Receptors - biosynthesis ; Immune response ; Immune Tolerance - immunology ; Interferon-gamma - biosynthesis ; Interleukin-13 - biosynthesis ; Interleukin-2 - biosynthesis ; Interleukin-2 - immunology ; Interleukin-4 - biosynthesis ; Ki-67 Antigen - biosynthesis ; Male ; Medical research ; Medicine, Experimental ; Mice ; Properties ; Receptors, Antigen, T-Cell - immunology ; Receptors, Interleukin-2 - immunology ; Signal Transduction - immunology ; T cells ; T-Lymphocytes, Regulatory - cytology ; T-Lymphocytes, Regulatory - immunology ; Tamoxifen - pharmacology
Is Part Of: Nature immunology, 2014-11, Vol.15 (11), p.1070-1078
Description: Foxp3(+) regulatory T cells (T(reg) cells) maintain immunological tolerance, and their deficiency results in fatal multiorgan autoimmunity. Although heightened signaling via the T cell antigen receptor (TCR) is critical for the differentiation of T(reg) cells, the role of TCR signaling in T(reg) cell function remains largely unknown. Here we demonstrated that inducible ablation of the TCR resulted in T(reg) cell dysfunction that could not be attributed to impaired expression of the transcription factor Foxp3, decreased expression of T(reg) cell signature genes or altered ability to sense and consume interleukin 2 (IL-2). Instead, TCR signaling was required for maintaining the expression of a limited subset of genes comprising 25% of the activated T(reg) cell transcriptional signature. Our results reveal a critical role for the TCR in the suppressor capacity of T(reg) cells.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1529-2908
EISSN: 1529-2916
DOI: 10.1038/ni.3004
PMID: 25263123
Source: AUTh Library subscriptions: ProQuest Central
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Continuous requirement for the TCR in regulatory T cell function

COPYRIGHT 2014 Nature Publishing Group ;COPYRIGHT 2014 Nature Publishing Group ;Copyright Nature Publishing Group Nov 2014 ;ISSN: 1529-2908 ;EISSN: 1529-2916 ;DOI: 10.1038/ni.3004 ;PMID: 25263123

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