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Mechanisms of TCDD-induction of cleft palate: Insights from in vivo and in vitro approaches

ISSN: 0045-6535 ;EISSN: 1879-1298

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  • Title:
    Mechanisms of TCDD-induction of cleft palate: Insights from in vivo and in vitro approaches
  • Author: Abbott, B D ; Diliberto, J J ; Birnbaum, L S
  • Damstra, T ; Greenlee, W ; Corton, C ; Lucier, G (eds) ; Charles, MJ ; Birnbaum, L
  • Description: TCDD induced cleft palate (CP) in C57BL6N embryos by altering proliferation and differentiation of palatal medial epithelial cells. These effects correlated with altered expression of the growth factors, TGF- alpha , EGF, TGF- beta 1 and TGF- beta 2, and the EGF receptor. Synergistic interactions between TCDD and retinoic acid (RA) or hydrocortisone (HC) resulted in CP induction at doses too low to induce CP if given alone. Clefts produced by TCDD + RA or TCDD + HC were due to growth inhibition, an outcome differing from that of TCDD alone. TCDD, RA, and HC all had different effects on growth factor expression with the strongest effects on TGF- beta , TGF- alpha , and EGF. In palatal organ culture, concentration-dependent effects on medial epithelial cells occurred in C57BL/6N mouse, F344 rat, and human palates. The responsiveness to TCDD was absent in serum-free cultures, suggesting that an additional factor is required in vitro.
  • Creation Date: 1992
  • Language: English
  • Identifier: ISSN: 0045-6535
    EISSN: 1879-1298
  • Source: Alma/SFX Local Collection
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