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Cardiovascular remodelling in coronary artery disease and heart failure

The Lancet (British edition), 2014-05, Vol.383 (9932), p.1933-1943 [Peer Reviewed Journal]

Elsevier Ltd ;2014 Elsevier Ltd ;2015 INIST-CNRS ;Copyright © 2014 Elsevier Ltd. All rights reserved. ;Copyright Elsevier Limited May 31, 2014 ;ISSN: 0140-6736 ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(14)60107-0 ;PMID: 24831770 ;CODEN: LANCAO

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Title:
Cardiovascular remodelling in coronary artery disease and heart failure
Author: Heusch, Gerd, Prof ; Libby, Peter, MD ; Gersh, Bernard, MBChB ; Yellon, Derek, Prof ; Böhm, Michael, Prof ; Lopaschuk, Gary, PhD ; Opie, Lionel, Prof
Subjects: Adaptation, Physiological - physiology ; Angina pectoris ; Atherosclerosis ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiovascular disease ; Coronary Artery Disease - physiopathology ; Coronary heart disease ; Coronary vessels ; Coronary Vessels - physiopathology ; Enzymes ; Gene expression ; General aspects ; Heart ; Heart attacks ; Heart failure ; Heart Failure - physiopathology ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Humans ; Hypertension ; Internal Medicine ; Ischemic Preconditioning, Myocardial - methods ; Medical sciences ; Mitochondria, Heart - metabolism ; Muscular system ; Myocardial Reperfusion Injury - physiopathology ; Oxidation-Reduction ; Rodents ; Smooth muscle ; Ventricular Remodeling - physiology
Is Part Of: The Lancet (British edition), 2014-05, Vol.383 (9932), p.1933-1943
Description: Summary Remodelling is a response of the myocardium and vasculature to a range of potentially noxious haemodynamic, metabolic, and inflammatory stimuli. Remodelling is initially functional, compensatory, and adaptive but, when sustained, progresses to structural changes that become self-perpetuating and pathogenic. Remodelling involves responses not only of the cardiomyocytes, endothelium, and vascular smooth muscle cells, but also of interstitial cells and matrix. In this Review we characterise the remodelling processes in atherosclerosis, vascular and myocardial ischaemia–reperfusion injury, and heart failure, and we draw attention to potential avenues for innovative therapeutic approaches, including conditioning and metabolic strategies.
Publisher: Kidlington: Elsevier Ltd
Language: English
Identifier: ISSN: 0140-6736
EISSN: 1474-547X
DOI: 10.1016/S0140-6736(14)60107-0
PMID: 24831770
CODEN: LANCAO
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Cardiovascular remodelling in coronary artery disease and heart failure

Elsevier Ltd ;2014 Elsevier Ltd ;2015 INIST-CNRS ;Copyright © 2014 Elsevier Ltd. All rights reserved. ;Copyright Elsevier Limited May 31, 2014 ;ISSN: 0140-6736 ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(14)60107-0 ;PMID: 24831770 ;CODEN: LANCAO

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