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Tumor-Infiltrating gamma delta T Lymphocytes Predict Clinical Outcome in Human Breast Cancer
The Journal of immunology (1950), 2012-11, Vol.189 (10), p.5029-5036
[Peer Reviewed Journal]
ISSN: 0022-1767 ;EISSN: 1550-6606 ;DOI: 10.4049/jimmunol.1201892
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Title:
Tumor-Infiltrating gamma delta T Lymphocytes Predict Clinical Outcome in Human Breast Cancer
Author:
Ma, Chunling
;
Zhang, Qunyuan
;
Ye, Jian
;
Wang, Fang
;
Zhang, Yanping
;
Wevers, Eric
;
Schwartz, Theresa
;
Hunborg, Pamela
;
Varvares, Mark A
;
Hoft, Daniel F
;
Hsueh, Eddy C
;
Peng, Guangyong
Is Part Of:
The Journal of immunology (1950), 2012-11, Vol.189 (10), p.5029-5036
Description:
Understanding and dissecting the role of different subsets of regulatory tumor-infiltrating lymphocytes (TILs) in the immunopathogenesis of individual cancer is a challenge for anti-tumor immunotherapy. High levels of gamma delta regulatory T cells have been discovered in breast TILs. However, the clinical relevance of these intratumoral gamma delta T cells is unknown. In this study, gamma delta T cell populations were analyzed by performing immunohistochemical staining in primary breast cancer tissues from patients with different stages of cancer progression. Retrospective multivariate analyses of the correlations between gamma delta T cell levels and other prognostic factors and clinical outcomes were completed. We found that gamma delta T cell infiltration and accumulation in breast tumor sites was a general feature in breast cancer patients. Intratumoral gamma delta T cell numbers were positively correlated with advanced tumor stages, HER2 expression status, and high lymph node metastasis but inversely correlated with relapse-free survival and overall survival of breast cancer patients. Multivariate and univariate analyses of tumor-infiltrating gamma delta T cells and other prognostic factors further suggested that intratumoral gamma delta T cells represented the most significant independent prognostic factor for assessing severity of breast cancer compared with the other known factors. Intratumoral gamma delta T cells were positively correlated with FOXP3+ cells and CD4+ T cells but negatively correlated with CD8+ T cells in breast cancer tissues. These findings suggest that intratumoral gamma delta T cells may serve as a valuable and independent prognostic biomarker, as well as a potential therapeutic target for human breast cancer.
Language:
English
Identifier:
ISSN: 0022-1767
EISSN: 1550-6606
DOI: 10.4049/jimmunol.1201892
Source:
GFMER Free Medical Journals
Alma/SFX Local Collection
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