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Manipulation of central blood volume and implications for respiratory control function

American journal of physiology. Heart and circulatory physiology, 2014-06, Vol.306 (12), p.H1669-H1678 [Peer Reviewed Journal]

Copyright © 2014 the American Physiological Society. ;Copyright American Physiological Society Jun 15, 2014 ;ISSN: 0363-6135 ;EISSN: 1522-1539 ;DOI: 10.1152/ajpheart.00987.2013 ;PMID: 24778171 ;CODEN: AJPPDI

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  • Title:
    Manipulation of central blood volume and implications for respiratory control function
  • Author: Miyamoto, Tadayoshi ; Bailey, Damian Miles ; Nakahara, Hidehiro ; Ueda, Shinya ; Inagaki, Masashi ; Ogoh, Shigehiko
  • Subjects: Adolescent ; Adult ; Blood ; Blood Volume - physiology ; Carbon Dioxide - metabolism ; Hemodynamics - physiology ; Humans ; Immersion - physiopathology ; Lower Body Negative Pressure ; Male ; Pulmonary Ventilation - physiology ; Respiratory Mechanics - physiology ; Respiratory system ; Tidal Volume - physiology ; Ventilation ; Volume ; Young Adult
  • Is Part Of: American journal of physiology. Heart and circulatory physiology, 2014-06, Vol.306 (12), p.H1669-H1678
  • Description: The respiratory operating point (ventilatory or arterial PCO2 response) is determined by the intersection point between the controller and plant subsystem elements within the respiratory control system. However, to what extent changes in central blood volume (CBV) influence these two elements and the corresponding implications for the respiratory operating point remain unclear. To examine this, 17 apparently healthy male participants were exposed to water immersion (WI) or lower body negative pressure (LBNP) challenges to manipulate CBV and determine the corresponding changes. The respiratory controller was characterized by determining the linear relationship between end-tidal PCO2 (PetCO2 ) and minute ventilation (Ve) [Ve = S × (PetCO2 - B)], whereas the plant was determined by the hyperbolic relationship between Ve and PetCO2 (PetCO2 = A/Ve + C). Changes in Ve at the operating point were not observed under either WI or LBNP conditions despite altered PetCO2 (P < 0.01), indicating a moving respiratory operating point. An increase (WI) and a decrease (LBNP) in CBV were shown to reset the controller element (PetCO2 intercept B) rightward and leftward, respectively (P < 0.05), without any change in S, whereas the plant curve remained unaltered at the operating point. Collectively, these findings indicate that modification of the controller element rather than the plant element is the major factor that contributes toward an alteration of the respiratory operating point during CBV shifts.
  • Publisher: United States: American Physiological Society
  • Language: English
  • Identifier: ISSN: 0363-6135
    EISSN: 1522-1539
    DOI: 10.1152/ajpheart.00987.2013
    PMID: 24778171
    CODEN: AJPPDI
  • Source: GFMER Free Medical Journals
    MEDLINE
    Alma/SFX Local Collection
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