Language:

Connective tissue growth factor and cardiac diastolic dysfunction: human data from the Taiwan Diastolic Heart Failure Registry and molecular basis by cellular and animal models

European journal of heart failure, 2014-02, Vol.16 (2), p.163-172 [Peer Reviewed Journal]

2013 The Authors. © 2013 European Society of Cardiology ;2013 The Authors. European Journal of Heart Failure © 2013 European Society of Cardiology. ;ISSN: 1388-9842 ;EISSN: 1879-0844 ;DOI: 10.1002/ejhf.33 ;PMID: 24464932

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Connective tissue growth factor and cardiac diastolic dysfunction: human data from the Taiwan Diastolic Heart Failure Registry and molecular basis by cellular and animal models
Author: Wu, Cho-Kai ; Wang, Yi-Chih ; Lee, Jen-Kuang ; Chang, Sheng-Nan ; Su, Mao-Yuan ; Yeh, Huei-Ming ; Su, Ming-Jai ; Chen, Jin-Jer ; Chiang, Fu-Tien ; Hwang, Juey-Jen ; Lin, Jiunn-Lee ; Tsai, Chia-Ti
Subjects: Aged ; Animals ; Canine model ; Connective tissue growth factor ; Connective Tissue Growth Factor - blood ; Connective Tissue Growth Factor - metabolism ; Connective Tissue Growth Factor - secretion ; Diastolic heart failure ; Disease Models, Animal ; Dogs ; Echocardiography, Doppler ; Female ; Fibrosis ; Heart Failure, Diastolic - diagnostic imaging ; Heart Failure, Diastolic - metabolism ; Heart Failure, Diastolic - pathology ; Humans ; Magnetic Resonance Imaging, Cine ; Male ; Mice ; Middle Aged ; Myocardium - pathology ; Myocytes, Cardiac - secretion ; Registries ; Severity of Illness Index
Is Part Of: European journal of heart failure, 2014-02, Vol.16 (2), p.163-172
Description: Aims Connective tissue growth factor (CTGF) is an emerging marker for tissue fibrosis. We investigated the association between CTGF and cardiac diastolic function using cellular and animal models and clinical human data. Methods and results A total of 125 patients with a diagnosis of diastolic heart failure (DHF) were recruited from 1283 patients of the Taiwan Diastolic Heart Failure Registry. The severity of DHF was determined by tissue Doppler imaging (E/e′). Cardiac magnetic resonance imaging (CMRI) was used to evaluate myocardial fibrosis in some of the patients (n = 25). Stretch of cardiomyocytes on a flexible membrane base serves as a cellular phenotype of cardiac diastolic dysfunction (DD). A canine model of DD was induced by aortic banding. A significant correlation was found between plasma CTGF and E/e′ in DHF patients. The severity of cardiac fibrosis evaluated by CMRI also correlated with CTGF. In the cell model, stretch increased secretion of CTGF from cardiomyocytes. In the canine model, myocardial tissue CTGF expression and fibrosis significantly increased after 2 weeks of aortic banding. Notably, the expression of CTGF paralleled the severity of LV DD (r = 0.40, P < 0.001 for E/e') and haemodynamic changes (r = 0.80, P < 0.001). After adjusting for confounding factors, CTGF levels still correlated with diastolic parameters in both human and canine models (human plasma CTGF, P < 0.001; canine tissue CTGF, P = 0.04). Conclusion Plasma CTGF level correlated with the severity of DD and tissue fibrosis in DHF patients. The mechanism may be through myocardial stretch. Our study indicated that CTGF may serve as an early marker for DHF.
Publisher: Oxford, UK: John Wiley & Sons, Ltd
Language: English
Identifier: ISSN: 1388-9842
EISSN: 1879-0844
DOI: 10.1002/ejhf.33
PMID: 24464932
Source: MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Connective tissue growth factor and cardiac diastolic dysfunction: human data from the Taiwan Diastolic Heart Failure Registry and molecular basis by cellular and animal models

2013 The Authors. © 2013 European Society of Cardiology ;2013 The Authors. European Journal of Heart Failure © 2013 European Society of Cardiology. ;ISSN: 1388-9842 ;EISSN: 1879-0844 ;DOI: 10.1002/ejhf.33 ;PMID: 24464932

Searching Remote Databases, Please Wait