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Intensive Chemotherapy for Childhood Acute Lymphoblastic Leukemia: Results of the Randomized Intercontinental Trial ALL IC-BFM 2002

Journal of clinical oncology, 2014-01, Vol.32 (3), p.174-184 [Peer Reviewed Journal]

2015 INIST-CNRS ;ISSN: 0732-183X ;EISSN: 1527-7755 ;DOI: 10.1200/JCO.2013.48.6522 ;PMID: 24344215

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Title:
Intensive Chemotherapy for Childhood Acute Lymphoblastic Leukemia: Results of the Randomized Intercontinental Trial ALL IC-BFM 2002
Author: STARY, Jan ; ZIMMERMANN, Martin ; KONJA, Josip ; KAISEROVA, Emilia ; KOWALCZYK, Jerzy ; GABOR, Kovacs ; LI, Chi-Kong ; MAGYAROSY, Edina ; POPA, Alexander ; STARK, Batia ; JABALI, Yahia ; TRKA, Jan ; CAMPBELL, Myriam ; HRUSAK, Ondrej ; RIEHM, Hansjorg ; MASERA, Giuseppe ; SCHRAPPE, Martin ; CASTILLO, Luis ; DIBAR, Eduardo ; DONSKA, Svetlana ; GONZALEZ, Alejandro ; IZRAELI, Shai ; JANIC, Dragana ; JAZBEC, Janez
Subjects: Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Asia - epidemiology ; Child ; Child, Preschool ; Disease-Free Survival ; Drug Resistance, Neoplasm ; Europe - epidemiology ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Infant ; International Cooperation ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - surgery ; Prospective Studies ; Recurrence ; Risk Assessment ; Risk Factors ; South America - epidemiology ; Treatment Outcome
Is Part Of: Journal of clinical oncology, 2014-01, Vol.32 (3), p.174-184
Description: From 2002 to 2007, the International Berlin-Frankfurt-Münster Study Group conducted a prospective randomized clinical trial (ALL IC-BFM 2002) for the management of childhood acute lymphoblastic leukemia (ALL) in 15 countries on three continents. The aim of this trial was to explore the impact of differential delayed intensification (DI) on outcome in all risk groups. For this trial, 5,060 eligible patients were divided into three risk groups according to age, WBC, early treatment response, and unfavorable genetic aberrations. DI was randomized as follows: standard risk (SR), two 4-week intensive elements (protocol III) versus one 7-week protocol II; intermediate risk (IR), protocol III × 3 versus protocol II × 1; high risk (HR), protocol III × 3 versus either protocol II × 2 (Associazione Italiana Ematologia Oncologia Pediatrica [AIEOP] option), or 3 HR blocks plus single protocol II (Berlin-Frankfurt-Münster [BFM] option). At 5 years, the probabilities of event-free survival and survival were 74% (± 1%) and 82% (± 1%) for all 5,060 eligible patients, 81% and 90% for the SR (n = 1,564), 75% and 83% for the IR (n = 2,650), and 55% and 62% for the HR (n = 846) groups, respectively. No improvement was accomplished by more intense and/or prolonged DI. The ALL IC-BFM 2002 trial is a good example of international collaboration in pediatric oncology. A wide platform of countries able to run randomized studies in ALL has been established. Although the alternative DI did not improve outcome compared with standard treatment and the overall results are worse than those achieved by longer established leukemia groups, the national results have generally improved.
Publisher: Alexandria, VA: American Society of Clinical Oncology
Language: English;Russian
Identifier: ISSN: 0732-183X
EISSN: 1527-7755
DOI: 10.1200/JCO.2013.48.6522
PMID: 24344215
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
Alma/SFX Local Collection

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Intensive Chemotherapy for Childhood Acute Lymphoblastic Leukemia: Results of the Randomized Intercontinental Trial ALL IC-BFM 2002

2015 INIST-CNRS ;ISSN: 0732-183X ;EISSN: 1527-7755 ;DOI: 10.1200/JCO.2013.48.6522 ;PMID: 24344215

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