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Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome

Nature genetics, 2012-09, Vol.44 (9), p.1020-1025 [Peer Reviewed Journal]

2015 INIST-CNRS ;COPYRIGHT 2012 Nature Publishing Group ;COPYRIGHT 2012 Nature Publishing Group ;Copyright Nature Publishing Group Sep 2012 ;ISSN: 1061-4036 ;EISSN: 1546-1718 ;DOI: 10.1038/ng.2384 ;PMID: 22885925 ;CODEN: NGENEC

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Title:
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome
Author: YONGYONG SHI ; HAN ZHAO ; JIAWEI SHEN ; JUNZHAO ZHAO ; LI YOU ; XUAN GAO ; DONGYI ZHU ; XIAOMING ZHAO ; YING YAN ; YINGYING QIN ; WENJIN LI ; JUNHAO YAN ; YUHUA SHI ; QINGZHONG WANG ; JUNLI ZHAO ; LING GENG ; JINLONG MA ; YUERAN ZHAO ; GUANG HE ; AIPING ZHANG ; SHUHUA ZOU ; AIJUN YANG ; JIAYIN LIU ; YUNXIA CAO ; WEIDONG LI ; BAOJIE LI ; CHUNLING WAN ; YING QIN ; JUANZI SHI ; JING YANG ; HONG JIANG ; XU, Jin-E ; XIUJUAN QI ; YUN SUN ; DONGZI YANG ; YAJIE ZHANG ; CUIFANG HAO ; XIUQING JU ; DONGNI ZHAO ; REN, Chun-E ; XIUQING LI ; WEI ZHANG ; YIWEN ZHANG ; JIANGTAO ZHANG ; DI WU ; ZHIQIANG LI ; CHANGMING ZHANG ; LIN HE ; CHEN, Zi-Jiang ; BO ZHANG ; XIAOYAN LIANG ; TAO LI ; JIANHUA CHEN
Subjects: Apoptosis ; Asian Continental Ancestry Group - genetics ; Asian Continental Ancestry Group - statistics & numerical data ; Biological and medical sciences ; Case-Control Studies ; Cell division ; Cohort Studies ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - ethnology ; Diabetes Mellitus, Type 2 - genetics ; Female ; Female genital diseases ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Genealogy ; Genetic aspects ; Genetic Loci ; Genetic Predisposition to Disease - ethnology ; Genetics of eukaryotes. Biological and molecular evolution ; Genome-Wide Association Study - statistics & numerical data ; Genomes ; Genotype ; Gynecology. Andrology. Obstetrics ; Health aspects ; Humans ; Independent sample ; Insulin resistance ; Logistics ; Medical sciences ; Meta-Analysis as Topic ; Non tumoral diseases ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - epidemiology ; Polycystic Ovary Syndrome - ethnology ; Polycystic Ovary Syndrome - genetics ; Polymorphism, Single Nucleotide - physiology ; Proteins ; Quantitative trait loci ; R&D ; Receptors, FSH - genetics ; Research & development ; Risk factors ; Stein-Leventhal syndrome ; Validation Studies as Topic ; Women
Is Part Of: Nature genetics, 2012-09, Vol.44 (9), p.1020-1025
Description: Following a previous genome-wide association study (GWAS 1) including 744 cases and 895 controls, we analyzed genome-wide association data from a new cohort of Han Chinese (GWAS 2) with 1,510 polycystic ovary syndrome (PCOS) cases and 2,016 controls. We followed up significantly associated signals identified in the combined results of GWAS 1 and 2 in a total of 8,226 cases and 7,578 controls. In addition to confirming the three loci we previously reported, we identify eight new PCOS association signals at P < 5 × 10(-8): 9q22.32, 11q22.1, 12q13.2, 12q14.3, 16q12.1, 19p13.3, 20q13.2 and a second independent signal at 2p16.3 (the FSHR gene). These PCOS association signals show evidence of enrichment for candidate genes related to insulin signaling, sexual hormone function and type 2 diabetes (T2D). Other candidate genes were related to calcium signaling and endocytosis. Our findings provide new insight and direction for discovering the biological mechanisms of PCOS.
Publisher: New York, NY: Nature Publishing Group
Language: English
Identifier: ISSN: 1061-4036
EISSN: 1546-1718
DOI: 10.1038/ng.2384
PMID: 22885925
CODEN: NGENEC
Source: GFMER Free Medical Journals
MEDLINE
ProQuest Central

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Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome

2015 INIST-CNRS ;COPYRIGHT 2012 Nature Publishing Group ;COPYRIGHT 2012 Nature Publishing Group ;Copyright Nature Publishing Group Sep 2012 ;ISSN: 1061-4036 ;EISSN: 1546-1718 ;DOI: 10.1038/ng.2384 ;PMID: 22885925 ;CODEN: NGENEC

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