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Eltrombopag before Procedures in Patients with Cirrhosis and Thrombocytopenia

The New England journal of medicine, 2012-08, Vol.367 (8), p.716-724 [Peer Reviewed Journal]

Copyright © 2012 Massachusetts Medical Society. All rights reserved. ;2015 INIST-CNRS ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1110709 ;PMID: 22913681 ;CODEN: NEJMAG

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Title:
Eltrombopag before Procedures in Patients with Cirrhosis and Thrombocytopenia
Author: Afdhal, Nezam H ; Giannini, Edoardo G ; Tayyab, Ghias ; Mohsin, Aftab ; Lee, Jin-Woo ; Andriulli, Angelo ; Jeffers, Lennox ; McHutchison, John ; Chen, Pei-Jer ; Han, Kwang-Hyub ; Campbell, Fiona ; Hyde, Denise ; Brainsky, Andres ; Theodore, Dickens
Subjects: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Benzoates - adverse effects ; Benzoates - therapeutic use ; Biological and medical sciences ; Bleeding ; Chronic Disease ; Cirrhosis ; Double-Blind Method ; Elective Surgical Procedures ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Hematologic and hematopoietic diseases ; Hemorrhage - epidemiology ; Hemorrhage - prevention & control ; Humans ; Hydrazines - adverse effects ; Hydrazines - therapeutic use ; Liver cirrhosis ; Liver Cirrhosis - complications ; Liver diseases ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical research ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Platelet Count ; Platelet diseases and coagulopathies ; Platelet Transfusion - statistics & numerical data ; Platelets ; Pyrazoles - adverse effects ; Pyrazoles - therapeutic use ; Receptors, Thrombopoietin - agonists ; Receptors, Thrombopoietin - genetics ; Thrombocytopenia ; Thrombocytopenia - complications ; Thrombopoietin ; Thrombosis ; Young Adult
Is Part Of: The New England journal of medicine, 2012-08, Vol.367 (8), p.716-724
Description: In this trial involving patients with cirrhosis and thrombocytopenia, treatment with eltrombopag before invasive procedures reduced the need for platelet transfusions. More thrombotic events of the portal venous system were observed with eltrombopag than with placebo. Thrombocytopenia is frequently observed in patients with chronic liver disease, with studies suggesting that it occurs in up to 76% of patients with cirrhosis. 1 – 3 The degree of thrombocytopenia is proportional to the severity of the liver disease. 4 , 5 Thrombocytopenia increases the risk of bleeding during and after invasive procedures and may result in the cancellation or postponement of elective procedures. 6 Platelet transfusions are commonly used to reduce the risk of bleeding during a procedure, but their short duration of efficacy and the risk of transfusion reactions limit their use. 7 , 8 Furthermore, the development of antiplatelet antibodies (alloimmunization) can cause . . .
Publisher: Waltham, MA: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa1110709
PMID: 22913681
CODEN: NEJMAG
Source: ProQuest One Psychology
AUTh Library subscriptions: ProQuest Central
MEDLINE
Alma/SFX Local Collection

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Eltrombopag before Procedures in Patients with Cirrhosis and Thrombocytopenia

Copyright © 2012 Massachusetts Medical Society. All rights reserved. ;2015 INIST-CNRS ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1110709 ;PMID: 22913681 ;CODEN: NEJMAG

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