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Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms

Nature reviews. Gastroenterology & hepatology, 2022-10, Vol.19 (10), p.625-637 [Peer Reviewed Journal]

2022. Springer Nature Limited. ;Springer Nature Limited 2022. corrected publication 2022. ;ISSN: 1759-5045 ;EISSN: 1759-5053 ;DOI: 10.1038/s41575-022-00631-9 ;PMID: 35641786

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  • Title:
    Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms
  • Author: Cani, Patrice D ; Depommier, Clara ; Derrien, Muriel ; Everard, Amandine ; de Vos, Willem M
  • Subjects: Akkermansia muciniphila ; Animal models ; Diabetes mellitus ; Fatty liver ; Metabolic disorders ; Microorganisms ; Steatosis
  • Is Part Of: Nature reviews. Gastroenterology & hepatology, 2022-10, Vol.19 (10), p.625-637
  • Description: Ever since Akkermansia muciniphila was discovered and characterized two decades ago, numerous studies have shown that the lack or decreased abundance of this commensal bacterium was linked with multiple diseases (such as obesity, diabetes, liver steatosis, inflammation and response to cancer immunotherapies). Although primarily based on simple associations, there are nowadays an increasing number of studies moving from correlations to causality. The causal evidence derived from a variety of animal models performed in different laboratories and recently was also recapitulated in a human proof-of-concept trial. In this Review, we cover the history of the discovery of A. muciniphila and summarize the numerous findings and main mechanisms of action by which this intestinal symbiont improves health. A comparison of this microorganism with other next-generation beneficial microorganisms that are being developed is also made.
  • Publisher: England: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 1759-5045
    EISSN: 1759-5053
    DOI: 10.1038/s41575-022-00631-9
    PMID: 35641786
  • Source: ProQuest Central
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