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068 Effect of low dose adjunctive perampanel in adults and adolescents with focal- onset seizures

Journal of neurology, neurosurgery and psychiatry, 2022-09, Vol.93 (9), p.e2 [Peer Reviewed Journal]

Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ. ;2022 Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ. ;ISSN: 0022-3050 ;EISSN: 1468-330X ;DOI: 10.1136/jnnp-2022-abn2.112

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  • Title:
    068 Effect of low dose adjunctive perampanel in adults and adolescents with focal- onset seizures
  • Author: Giallonardo, Anna Teresa ; Aguglia, Umberto ; Goldman, Samantha ; Chiacchiaretta, Martina ; Gentile, Anna ; Patten, Anna
  • Subjects: ABN Abstracts 2022 ; Teenagers
  • Is Part Of: Journal of neurology, neurosurgery and psychiatry, 2022-09, Vol.93 (9), p.e2
  • Description: BackgroundWe report a post hoc analysis of the efficacy and safety of low dose adjunctive perampanel 4 mg/day in adults and adolescents from A Mirroring Clinical Practice Study in Italy (AMPA; NCT04257604).MethodsAMPA was a prospective, observational study in patients aged ≥12 years with focal-onset seizures (FOS). Patients were prescribed adjunctive perampanel per the approved indication. Seizure diaries and treatment-emergent adverse events (TEAEs) were verified at baseline and study visits. The primary endpoint was change from baseline in seizure frequency/28 days at Month 6. Secondary endpoints included: 50% and 75% responder rates, seizure-freedom rates, retention rates and safety (≤12 months).ResultsOf the 234 patients who received adjunctive perampanel, 62 (26.5%) received a modal peram- panel dose of 4 mg/day and were included in the Safety Analysis Set. The 6-month median reduction from baseline in all-seizure frequency was 55.4% (95% confidence interval, 31.7%-90.3%). The 12-month 50% and 75% responder, seizure-freedom and retention rates were 57.1%, 46.9%, 26.0% and 46.8%, respec- tively. TEAEs occurred in 50% of patients; the most common TEAE was dizziness/vertigo (17.7% [n=11]).ConclusionsAdjunctive perampanel at 4 mg/day is efficacious and safe in adult and adolescent patients with FOS in a real-world clinical setting. Funding: Eisai s.r.l.
  • Publisher: London: BMJ Publishing Group Ltd
  • Language: English
  • Identifier: ISSN: 0022-3050
    EISSN: 1468-330X
    DOI: 10.1136/jnnp-2022-abn2.112
  • Source: ProQuest One Psychology
    AUTh Library subscriptions: ProQuest Central
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