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Biomarkers for brain injury and copper toxicity in Wilson’s disease: a diffusion tensor imaging study

Journal of neurology, neurosurgery and psychiatry, 2022-06, Vol.93 (6), p.A94-A94 [Peer Reviewed Journal]

Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ. ;2022 Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ. ;ISSN: 0022-3050 ;EISSN: 1468-330X ;DOI: 10.1136/jnnp-2022-ABN.304

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  • Title:
    Biomarkers for brain injury and copper toxicity in Wilson’s disease: a diffusion tensor imaging study
  • Author: Shribman, Samuel ; Bocchetta, Martina ; Burrows, Maggie ; Gillett, Godfrey T ; Tsochatzis, Emmanuel ; Bandmann, Oliver ; Rohrer, Jonathan D ; Warner, Thomas T
  • Subjects: ABN Abstracts 2021 ; Biomarkers ; Traumatic brain injury
  • Is Part Of: Journal of neurology, neurosurgery and psychiatry, 2022-06, Vol.93 (6), p.A94-A94
  • Description: IntroductionChelation therapy is used to ‘de-copper’ patients with Wilson’s disease but neurological outcomes are unpredictable and biomarkers of end-organ damage are needed.MethodsWe prospectively performed clinical assessments, venepuncture and 3T MRI in 40 patients with Wilson’s disease. Using tract-based spatial statistics, we compared diffusion tensor imaging parameters across white matter tracts between patients with neurological (n=23) and hepatic (n=17) presentations and active (n=5) and stable (n=35) disease. We also tested associations with neurological examination scores and serum free copper concentrations in stable patients.ResultsThere were no differences in DTI parameters between patients with neurological and hepatic presentations, however examination scores were negatively associated with axial diffusivity in subcortical tracts in stable patients. Patients with active disease had widespread increases in mean, axial and, to a lesser extent, radial diffusivity. In contrast, increasing serum copper concentrations in stable patients were associated with widespread increases in mean, radial and, to a lesser extent, axial diffusivity.ConclusionsWe demonstrate that distinct patterns of abnormal white matter diffusivity are associated with brain injury and copper toxicity in Wilson’s disease. Decreases in axial diffusivity in chronically-treated patients likely reflect axonal loss. Increases in axial and radial diffusivity are a promising biomarker for monitoring treatment response.s.shribman@ucl.ac.uk
  • Publisher: London: BMJ Publishing Group Ltd
  • Language: English
  • Identifier: ISSN: 0022-3050
    EISSN: 1468-330X
    DOI: 10.1136/jnnp-2022-ABN.304
  • Source: ProQuest One Psychology
    ProQuest Central
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