skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Effect of shikonin on improving atrial fibrillation of rats by inhibiting ERK1/2-NF-κB pathway

Jie fang jun yi xue za zhi, 2021-01, Vol.46 (8), p.757 [Peer Reviewed Journal]

2021] This work is licensed under [CC BY 3.0 Unported - https://creativecommons.org/licenses/by/3.0/ (“the License”). Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the terms of the License. ;ISSN: 0577-7402 ;DOI: 10.11855/j.issn.0577-7402.2021.08.03

Full text available

Citations Cited by
  • Title:
    Effect of shikonin on improving atrial fibrillation of rats by inhibiting ERK1/2-NF-κB pathway
  • Author: Li-Liang, SHU ; Gong-Cheng, HUANG ; HAO, Shuang ; HUANG, Chen ; Xiao-Hua, ZHU ; XU, Jing
  • Subjects: Cardiac arrhythmia ; Cardiomyocytes ; Collagen ; Proteins
  • Is Part Of: Jie fang jun yi xue za zhi, 2021-01, Vol.46 (8), p.757
  • Description: Objective　To investigate the effect of shikonin on atrial fibrillation of rats with myocardial fibrosis mediated by extracellular signal-regulated protein kinase1/2(ERK1/2)/nuclear transcription factor-kappaB (NF-κB). Methods　Thirty SD rats were randomly divided into normal control group, model group, shikonin group (10 each). Rats in shikonin group were intragastrically given shikonin 4 mg/kg, in normal control and model groups were given the same amount of normal saline, 1 time/d for consecutive 7 days; Rats in model and shikonin groups were tail intravenous injected with 1 ml/kg ACh-CaCl2 mixed liquor to establish atrial fibrillation model, 1 time/d for consecutive 7 days, and in normal control group were injected with the same amount of normal saline, taken materials after 7 days. Electrocardiogram was used to record the induced time and duration of atrial fibrillation, and the cardiac function was detected by echocardiography. The pathological condition of myocardial tissue was observed by HE staining. M
  • Publisher: Beijing: People's Military Medical Press
  • Language: Chinese
  • Identifier: ISSN: 0577-7402
    DOI: 10.11855/j.issn.0577-7402.2021.08.03
  • Source: ProQuest Central
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait