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Rescue Use of Beclomethasone and Albuterol in a Single Inhaler for Mild Asthma

The New England journal of medicine, 2007-05, Vol.356 (20), p.2040-2052 [Peer Reviewed Journal]

Copyright © 2007 Massachusetts Medical Society. All rights reserved. ;2007 INIST-CNRS ;Copyright 2007 Massachusetts Medical Society. ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa063861 ;PMID: 17507703 ;CODEN: NEJMAG

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Title:
Rescue Use of Beclomethasone and Albuterol in a Single Inhaler for Mild Asthma
Author: Papi, Alberto ; Canonica, Giorgio W ; Maestrelli, Piero ; Paggiaro, Pierluigi ; Olivieri, Dario ; Pozzi, Ernesto ; Crimi, Nunzio ; Vignola, Antonio M ; Morelli, Paolo ; Nicolini, Gabriele ; Fabbri, Leonardo M
Subjects: Administration, Inhalation ; Adrenergic beta-Agonists - administration & dosage ; Adrenergic beta-Agonists - adverse effects ; Adult ; Albuterol ; Albuterol - administration & dosage ; Albuterol - adverse effects ; Anti-Asthmatic Agents - administration & dosage ; Anti-Asthmatic Agents - adverse effects ; Asthma ; Asthma - drug therapy ; Asthma - physiopathology ; Beclomethasone - administration & dosage ; Beclomethasone - adverse effects ; Beclomethasone dipropionate ; Biological and medical sciences ; Chronic obstructive pulmonary disease, asthma ; Dosage and administration ; Double-Blind Method ; Drug Combinations ; Drug therapy ; Female ; Forced Expiratory Volume ; General aspects ; Glucocorticoids - administration & dosage ; Glucocorticoids - adverse effects ; Humans ; Inhalers ; Male ; Medical sciences ; Middle Aged ; Nebulizers and Vaporizers ; Peak Expiratory Flow Rate ; Pneumology
Is Part Of: The New England journal of medicine, 2007-05, Vol.356 (20), p.2040-2052
Description: Patients with mild persistent asthma are often advised to use inhaled corticosteroids on a regular schedule. In this trial, such patients treated themselves with inhaled beclomethasone (250 μg per puff) and albuterol (100 μg per puff) only when they had symptoms of asthma. The mean morning peak expiratory flow rate in this group was similar to that in the group receiving inhaled corticosteroids regularly. Controller treatments may not be needed on a regular basis in patients with asthma. In this trial, patients treated themselves with inhaled beclomethasone and albuterol only when they had symptoms of asthma. The mean morning peak expiratory flow rate in this group was similar to that in the group receiving inhaled corticosteroids regularly. Treatment guidelines for asthma 1 , 2 recommend regular treatment with inhaled corticosteroids for patients with mild persistent asthma, since this treatment regimen provides control of asthma, 3 – 7 suppresses airway inflammation, 8 , 9 and may prevent the progression of asthma. 4 – 6 , 10 Although the doubling of the dose of inhaled corticosteroids has been reported to be ineffective in preventing exacerbation of asthma, 11 , 12 high-dose inhaled corticosteroids administered at the onset of an exacerbation have been reported to enhance the control of asthma. 13 In addition, the control of mild persistent asthma achieved with the use of short courses of high-dose inhaled corticosteroids is similar . . .
Publisher: Boston, MA: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa063861
PMID: 17507703
CODEN: NEJMAG
Source: ProQuest One Psychology
MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Rescue Use of Beclomethasone and Albuterol in a Single Inhaler for Mild Asthma

Copyright © 2007 Massachusetts Medical Society. All rights reserved. ;2007 INIST-CNRS ;Copyright 2007 Massachusetts Medical Society. ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa063861 ;PMID: 17507703 ;CODEN: NEJMAG

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