Language:

Major Cardiac Events and the Value of Echocardiographic Evaluation in Patients Receiving Anthracycline-Based Chemotherapy

The American journal of cardiology, 2015-08, Vol.116 (3), p.442-446 [Peer Reviewed Journal]

Elsevier Inc. ;2015 Elsevier Inc. ;Copyright © 2015 Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Aug 1, 2015 ;ISSN: 0002-9149 ;EISSN: 1879-1913 ;DOI: 10.1016/j.amjcard.2015.04.064 ;PMID: 26071994 ;CODEN: AJCDAG

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Major Cardiac Events and the Value of Echocardiographic Evaluation in Patients Receiving Anthracycline-Based Chemotherapy
Author: Wang, Lin, MD ; Tan, Timothy C., MD ; Halpern, Elkan F., PhD ; Neilan, Tomas G., MD ; Francis, Sanjeev A., MD ; Picard, Michael H., MD ; Fei, Hongwen, MD, PhD ; Hochberg, Ephraim P., MD ; Abramson, Jeremy S., MD ; Weyman, Arthur E., MD ; Kuter, Irene, MD, DPhil ; Scherrer-Crosbie, Marielle, MD, PhD
Subjects: Anthracyclines - adverse effects ; Anthracyclines - therapeutic use ; Cancer therapies ; Cardiology ; Cardiomyopathy ; Cardiovascular ; Cardiovascular disease ; Cardiovascular Diseases - chemically induced ; Cardiovascular Diseases - diagnostic imaging ; Cardiovascular Diseases - epidemiology ; Chemotherapy ; Coronary vessels ; Diabetes ; Echocardiography - methods ; Enzymes ; Female ; Follow-Up Studies ; Heart attacks ; Heart Ventricles - diagnostic imaging ; Heart Ventricles - drug effects ; Heart Ventricles - physiopathology ; Humans ; Hypertension ; Incidence ; Male ; Massachusetts - epidemiology ; Middle Aged ; Mortality ; Neoplasms - drug therapy ; Prognosis ; Retrospective Studies ; Risk Factors ; Stroke Volume - drug effects ; Studies ; Ultrasonic imaging ; Variables ; Ventricular Function, Left - drug effects
Is Part Of: The American journal of cardiology, 2015-08, Vol.116 (3), p.442-446
Description: Anthracyclines are an important component of cancer treatments; however, their use is limited by the occurrence of cardiotoxicity. There are limited data on the occurrence of heart failure and the value of baseline and follow-up measurements of left ventricular (LV) ejection fraction (EF) in the current era. Therefore, the objectives of the present study were twofold: (1) to characterize the occurrence of and risk factors for major adverse cardiac events (MACEs: symptomatic heart failure and cardiac death) in a large contemporaneous population of adult patients treated with anthracyclines and (2) to test the value of LVEF and LV dimensions obtained using echocardiography in the prediction of MACE. Five thousand fifty-seven patients were studied, of whom 124 (2.4%) developed MACE. Of the total cohort, 2,285 patients had an available echocardiogram pre-chemotherapy. Patients with MACE were older (p <0.0001), predominantly men (p = 0.03), and with a higher incidence of cardiovascular risk factors and cardiac treatments. Patients with hematologic cancers had a higher incidence of cardiac events than patients with breast cancer (4.2% vs 0.7%, p <0.0001). Baseline LVEF, LVEF ≤5 points above the lower limits of normal, and LV internal diameter were predictive of the rate of occurrence of MACE. In conclusion, older patients with hematologic cancers and patients with a baseline LVEF ≤5 points above the lower limit of normal have higher incidence of MACE and should be closely monitored.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0002-9149
EISSN: 1879-1913
DOI: 10.1016/j.amjcard.2015.04.064
PMID: 26071994
CODEN: AJCDAG
Source: MEDLINE
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Major Cardiac Events and the Value of Echocardiographic Evaluation in Patients Receiving Anthracycline-Based Chemotherapy

Elsevier Inc. ;2015 Elsevier Inc. ;Copyright © 2015 Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Aug 1, 2015 ;ISSN: 0002-9149 ;EISSN: 1879-1913 ;DOI: 10.1016/j.amjcard.2015.04.064 ;PMID: 26071994 ;CODEN: AJCDAG

Searching Remote Databases, Please Wait