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Households as foci for dengue transmission in highly urban Vietnam

PLoS neglected tropical diseases, 2015-02, Vol.9 (2), p.e0003528 [Peer Reviewed Journal]

COPYRIGHT 2015 Public Library of Science ;COPYRIGHT 2015 Public Library of Science ;2015 Anders et al 2015 Anders et al ;2015 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Anders KL, Nga LH, Thuy NTV, Ngoc TV, Tam CT, Tai LTH, et al. (2015) Households as Foci for Dengue Transmission in Highly Urban Vietnam. PLoS Negl Trop Dis 9(2): e0003528. doi:10.1371/journal.pntd.0003528 ;ISSN: 1935-2735 ;ISSN: 1935-2727 ;EISSN: 1935-2735 ;DOI: 10.1371/journal.pntd.0003528 ;PMID: 25680106

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Title:
Households as foci for dengue transmission in highly urban Vietnam
Author: Anders, Katherine L ; Nga, Le Hong ; Thuy, Nguyen Thi Van ; Ngoc, Tran Van ; Tam, Cao Thi ; Tai, Luong Thi Hue ; Truong, Nguyen Thanh ; Duyen, Huynh Thi Le ; Trung, Vu Tuan ; Kien, Duong Thi Hue ; Wolbers, Marcel ; Wills, Bridget ; Chau, Nguyen Van Vinh ; Tho, Nguyen Dac ; Simmons, Cameron P
Halstead, Scott B
Subjects: Adolescent ; Adult ; Aedes - virology ; Animals ; Child ; Child, Preschool ; Cities ; Cluster Analysis ; Data collection ; Dengue ; Dengue - epidemiology ; Dengue - prevention & control ; Dengue - transmission ; Dengue fever ; Dengue Virus - classification ; Disease transmission ; Distribution ; Enzyme-Linked Immunosorbent Assay ; Female ; Forecasts and trends ; Health aspects ; Health care ; Households ; Humans ; Infections ; Insect Vectors - virology ; Insecticides - administration & dosage ; Laboratories ; Male ; Middle Aged ; Mosquitoes ; Prospective Studies ; Public health administration ; Rural Population ; Studies ; Urban Population ; Vaccines ; Vietnam - epidemiology ; Young Adult
Is Part Of: PLoS neglected tropical diseases, 2015-02, Vol.9 (2), p.e0003528
Description: Dengue control programs commonly employ reactive insecticide spraying around houses of reported cases, with the assumption that most dengue virus (DENV) transmission occurs in the home. Focal household transmission has been demonstrated in rural settings, but it is unclear whether this holds true in dense and mobile urban populations. We conducted a prospective study of dengue clustering around households in highly urban Ho Chi Minh City, Vietnam. We enrolled 71 index cases with suspected dengue (subsequently classified as 52 dengue cases and 19 non-dengue controls); each initiated the enrollment of a cluster of 25-35 household members and neighbors who were followed up over 14 days. Incident DENV infections in cluster participants were identified by RT-PCR, NS1-ELISA, and/or DENV-IgM/-IgG seroconversion, and recent infections by DENV-IgM positivity at baseline. There was no excess risk of DENV infection within dengue case clusters during the two-week follow-up, compared to control clusters, but the prevalence of recent DENV infection at baseline was two-fold higher in case clusters than controls (OR 2.3, 95%CI 1.0-5.1, p = 0.05). Prevalence of DENV infection in Aedes aegypti was similar in case and control houses, and low overall (1%). Our findings are broadly consistent with household clustering of dengue risk, but indicate that any clustering is at a short temporal scale rather than sustained chains of localized transmission. This suggests that reactive perifocal insecticide spraying may have a limited impact in this setting.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1935-2735
ISSN: 1935-2727
EISSN: 1935-2735
DOI: 10.1371/journal.pntd.0003528
PMID: 25680106
Source: Public Library of Science (PLoS) Journals Open Access
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Households as foci for dengue transmission in highly urban Vietnam

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