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Using multiple types of studies in systematic reviews of health care interventions--a systematic review

PloS one, 2013-12, Vol.8 (12), p.e85035-e85035 [Peer Reviewed Journal]

COPYRIGHT 2013 Public Library of Science ;2013 Peinemann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2013 Peinemann et al 2013 Peinemann et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0085035 ;PMID: 24416098

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  • Title:
    Using multiple types of studies in systematic reviews of health care interventions--a systematic review
  • Author: Peinemann, Frank ; Tushabe, Doreen Allen ; Kleijnen, Jos
  • Briel, Matthias
  • Subjects: Clinical trials ; Clinical Trials as Topic ; Controlled vocabularies ; Design ; Epidemiology ; Evidence-based medicine ; Health care ; HIV ; Human immunodeficiency virus ; Immunotherapy ; Integration ; Intervention ; Literature reviews ; Medical research ; Primary care ; Public health ; PubMed ; Randomization ; Reproducibility of Results ; Research Design ; Review Literature as Topic ; Studies ; Systematic review
  • Is Part Of: PloS one, 2013-12, Vol.8 (12), p.e85035-e85035
  • Description: A systematic review may evaluate different aspects of a health care intervention. To accommodate the evaluation of various research questions, the inclusion of more than one study design may be necessary. One aim of this study is to find and describe articles on methodological issues concerning the incorporation of multiple types of study designs in systematic reviews on health care interventions. Another aim is to evaluate methods studies that have assessed whether reported effects differ by study types. We searched PubMed, the Cochrane Database of Systematic Reviews, and the Cochrane Methodology Register on 31 March 2012 and identified 42 articles that reported on the integration of single or multiple study designs in systematic reviews. We summarized the contents of the articles qualitatively and assessed theoretical and empirical evidence. We found that many examples of reviews incorporating multiple types of studies exist and that every study design can serve a specific purpose. The clinical questions of a systematic review determine the types of design that are necessary or sufficient to provide the best possible answers. In a second independent search, we identified 49 studies, 31 systematic reviews and 18 trials that compared the effect sizes between randomized and nonrandomized controlled trials, which were statistically different in 35%, and not different in 53%. Twelve percent of studies reported both, different and non-different effect sizes. Different study designs addressing the same question yielded varying results, with differences in about half of all examples. The risk of presenting uncertain results without knowing for sure the direction and magnitude of the effect holds true for both nonrandomized and randomized controlled trials. The integration of multiple study designs in systematic reviews is required if patients should be informed on the many facets of patient relevant issues of health care interventions.
  • Publisher: United States: Public Library of Science
  • Language: English
  • Identifier: ISSN: 1932-6203
    EISSN: 1932-6203
    DOI: 10.1371/journal.pone.0085035
    PMID: 24416098
  • Source: Public Library of Science (PLoS) Journals Open Access
    DOAJ Directory of Open Access Journals
    Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    PubMed Central
    ProQuest Central
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