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Progression of kidney disease in non-diabetic patients with coronary artery disease: predictive role of circulating matrix metalloproteinase-2, -3, and -9

PloS one, 2013-07, Vol.8 (7), p.e70132-e70132 [Peer Reviewed Journal]

COPYRIGHT 2013 Public Library of Science ;2013 Hsu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2013 Hsu et al 2013 Hsu et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0070132 ;PMID: 23922934

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Title:
Progression of kidney disease in non-diabetic patients with coronary artery disease: predictive role of circulating matrix metalloproteinase-2, -3, and -9
Author: Hsu, Ta-Wei ; Kuo, Ko-Lin ; Hung, Szu-Chun ; Huang, Po-Hsun ; Chen, Jaw-Wen ; Tarng, Der-Cherng
Câmara, Niels Olsen Saraiva
Subjects: Aged ; Angina pectoris ; Angiography ; Biology ; Cardiology ; Cardiovascular disease ; Care and treatment ; Chronic kidney failure ; Clinical medicine ; Coronary artery ; Coronary artery disease ; Coronary Artery Disease - complications ; Coronary heart disease ; Coronary vessels ; Development and progression ; Diabetes ; Diabetes mellitus ; Diabetics ; Epidermal growth factor receptors ; Female ; Gelatinase A ; Gelatinase B ; Gene expression ; Glomerular Filtration Rate ; Health risks ; Heart diseases ; Humans ; Kidney - physiopathology ; Kidney diseases ; Kidney Diseases - blood ; Kidney Diseases - complications ; Kidney Diseases - diagnosis ; Kidney Diseases - physiopathology ; Kidney transplantation ; Kinases ; Laboratories ; Male ; Matrix metalloproteinase ; Matrix Metalloproteinase 2 - blood ; Matrix Metalloproteinase 3 - blood ; Matrix Metalloproteinase 9 - blood ; Medical imaging ; Medical research ; Medicine ; Medicine, Experimental ; Metalloproteinase ; Middle Aged ; Mortality ; Nephrology ; Patients ; Prognosis ; Prospective Studies ; Regression analysis ; Regression models ; Risk analysis ; Risk factors ; Rodents ; Sensitivity analysis ; Statistical analysis ; Stenosis ; Stromelysin 1
Is Part Of: PloS one, 2013-07, Vol.8 (7), p.e70132-e70132
Description: Circulating matrix metalloproteinase (MMP)-2, -3 and -9 are well recognized in predicting cardiovascular outcome in coronary artery disease (CAD), but their risks for chronic kidney disease (CKD) are lacking. Therefore, the present study aimed to investigate whether circulating MMP levels could independently predict future kidney disease progression in non-diabetic CAD patients. The prospective study enrolled 251 non-diabetic subjects referred for coronary angiography, containing normal coronary artery (n = 30) and CAD with insignificant (n = 95) and significant (n = 126) stenosis. Estimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI formula. eGFR decline rate was calculated and the primary endpoint was a decline in eGFR over 25% from baseline. The eGFR decline rate (ml/min/1.73 m(2) per year) in patients with CAD (1.22 [-1.27, 1.05]) was greater than that in those with normal coronary artery (0.21 [-2.63, 0.47], P<0.01). The circulating MMP-2, -3 and -9 were independently associated with faster eGFR decline among CAD patients. The mean follow-up period was 8.5±2.4 years, and 39 patients reached the primary endpoint. In multivariate Cox regression model, the adjusted hazard ratios of MMP-2 ≥861 ng/mL, MMP-3 ≥227 ng/mL and MMP-9 ≥49 ng/mL for predicting CKD progression were 2.47 (95% CI, 1.21 to 5.07), 2.15 (1.12 to 4.18), and 4.71 (2.14 to 10.4), respectively. While added to a model of conventional risk factors and baseline eGFR, MMP-2, -3 and -9 further significantly improved the model predictability for CKD progression (c statistic, 0.817). In the sensitivity analyses, the results were similar no matter if we changed the endpoints of a decline of >20% in eGFR from baseline or final eGFR < 60 mL/min/1.73 m(2). Circulating MMP-2, -3 and -9 are independently associated with kidney disease progression in non-diabetic CAD patients and add incremental predictive power to conventional risk factors.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0070132
PMID: 23922934
Source: Geneva Foundation Free Medical Journals
PubMed Central (Open access)
AUTh Library subscriptions: ProQuest Central
MEDLINE
Public Library of Science（OA）
DOAJ Directory of Open Access Journals

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Progression of kidney disease in non-diabetic patients with coronary artery disease: predictive role of circulating matrix metalloproteinase-2, -3, and -9

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