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The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism

PLoS genetics, 2012-07, Vol.8 (7), p.e1002816-e1002816 [Peer Reviewed Journal]

COPYRIGHT 2012 Public Library of Science ;COPYRIGHT 2012 Public Library of Science ;2012 Bayram et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Bayram Ö, Bayram ÖS, Ahmed YL, Maruyama J-i, Valerius O, et al. (2012) The Aspergillus nidulans MAPK Module AnSte11-Ste50-Ste7-Fus3 Controls Development and Secondary Metabolism. PLoS Genet 8(7): e1002816. doi:10.1371/journal.pgen.1002816 ;Bayram et al. 2012 ;ISSN: 1553-7404 ;ISSN: 1553-7390 ;EISSN: 1553-7404 ;DOI: 10.1371/journal.pgen.1002816 ;PMID: 22829779

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Title:
The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism
Author: Bayram, Özgür ; Bayram, Özlem Sarikaya ; Ahmed, Yasar Luqman ; Maruyama, Jun-Ichi ; Valerius, Oliver ; Rizzoli, Silvio O ; Ficner, Ralf ; Irniger, Stefan ; Braus, Gerhard H
Madhani, Hiten D.
Subjects: Aspergillus ; Aspergillus nidulans - growth & development ; Aspergillus nidulans - metabolism ; Biology ; Cell Membrane - metabolism ; Cell Nucleus - metabolism ; Enzymes ; Fungi ; Genetic aspects ; Health aspects ; Kinases ; MAP Kinase Kinase Kinases - genetics ; MAP Kinase Kinase Kinases - metabolism ; MAP Kinase Signaling System - genetics ; MAP Kinase Signaling System - physiology ; Metabolism ; Microbial genetics ; Mitogen-Activated Protein Kinase Kinases - genetics ; Mitogen-Activated Protein Kinase Kinases - metabolism ; Mitogen-activated protein kinases ; Mitogen-Activated Protein Kinases - genetics ; Mitogen-Activated Protein Kinases - metabolism ; Nuclear Envelope - metabolism ; Pheromones ; Pheromones - genetics ; Pheromones - metabolism ; Physiological aspects ; Protein Kinases - genetics ; Protein Kinases - metabolism ; Proteins ; Saccharomyces cerevisiae - growth & development ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae Proteins - genetics ; Saccharomyces cerevisiae Proteins - metabolism ; Sexual Development - genetics ; Signal Transduction
Is Part Of: PLoS genetics, 2012-07, Vol.8 (7), p.e1002816-e1002816
Description: The sexual Fus3 MAP kinase module of yeast is highly conserved in eukaryotes and transmits external signals from the plasma membrane to the nucleus. We show here that the module of the filamentous fungus Aspergillus nidulans (An) consists of the AnFus3 MAP kinase, the upstream kinases AnSte7 and AnSte11, and the AnSte50 adaptor. The fungal MAPK module controls the coordination of fungal development and secondary metabolite production. It lacks the membrane docking yeast Ste5 scaffold homolog; but, similar to yeast, the entire MAPK module's proteins interact with each other at the plasma membrane. AnFus3 is the only subunit with the potential to enter the nucleus from the nuclear envelope. AnFus3 interacts with the conserved nuclear transcription factor AnSte12 to initiate sexual development and phosphorylates VeA, which is a major regulatory protein required for sexual development and coordinated secondary metabolite production. Our data suggest that not only Fus3, but even the entire MAPK module complex of four physically interacting proteins, can migrate from plasma membrane to nuclear envelope.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1553-7404
ISSN: 1553-7390
EISSN: 1553-7404
DOI: 10.1371/journal.pgen.1002816
PMID: 22829779
Source: Public Library of Science (PLoS) Journals Open Access
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism

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