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Mapping protein interactions between Dengue virus and its human and insect hosts

PLoS neglected tropical diseases, 2011-02, Vol.5 (2), p.e954-e954 [Peer Reviewed Journal]

2011 Doolittle, Gomez. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Doolittle JM, Gomez SM (2011) Mapping Protein Interactions between Dengue Virus and Its Human and Insect Hosts. PLoS Negl Trop Dis 5(2): e954. doi:10.1371/journal.pntd.0000954 ;Doolittle, Gomez. 2011 ;ISSN: 1935-2735 ;ISSN: 1935-2727 ;EISSN: 1935-2735 ;DOI: 10.1371/journal.pntd.0000954 ;PMID: 21358811

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Title:
Mapping protein interactions between Dengue virus and its human and insect hosts
Author: Doolittle, Janet M ; Gomez, Shawn M
Chen, Cheng-Chen
Subjects: Aedes - virology ; Animals ; Biochemistry/Structural Genomics ; Computational Biology - methods ; Computational Biology/Protein Homology Detection ; Computational Biology/Protein Structure Prediction ; Computational Biology/Signaling Networks ; Computational Biology/Systems Biology ; Dengue Virus - pathogenicity ; Host-Pathogen Interactions ; Humans ; Infectious Diseases/Neglected Tropical Diseases ; Infectious Diseases/Tropical and Travel-Associated Diseases ; Infectious Diseases/Viral Infections ; Molecular Biology/Bioinformatics ; Protein Interaction Mapping ; Virology/Immune Evasion ; Virology/Viral and Gene Regulation
Is Part Of: PLoS neglected tropical diseases, 2011-02, Vol.5 (2), p.e954-e954
Description: Dengue fever is an increasingly significant arthropod-borne viral disease, with at least 50 million cases per year worldwide. As with other viral pathogens, dengue virus is dependent on its host to perform the bulk of functions necessary for viral survival and replication. To be successful, dengue must manipulate host cell biological processes towards its own ends, while avoiding elimination by the immune system. Protein-protein interactions between the virus and its host are one avenue through which dengue can connect and exploit these host cellular pathways and processes. We implemented a computational approach to predict interactions between Dengue virus (DENV) and both of its hosts, Homo sapiens and the insect vector Aedes aegypti. Our approach is based on structural similarity between DENV and host proteins and incorporates knowledge from the literature to further support a subset of the predictions. We predict over 4,000 interactions between DENV and humans, as well as 176 interactions between DENV and A. aegypti. Additional filtering based on shared Gene Ontology cellular component annotation reduced the number of predictions to approximately 2,000 for humans and 18 for A. aegypti. Of 19 experimentally validated interactions between DENV and humans extracted from the literature, this method was able to predict nearly half (9). Additional predictions suggest specific interactions between virus and host proteins relevant to interferon signaling, transcriptional regulation, stress, and the unfolded protein response. Dengue virus manipulates cellular processes to its advantage through specific interactions with the host's protein interaction network. The interaction networks presented here provide a set of hypothesis for further experimental investigation into the DENV life cycle as well as potential therapeutic targets.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1935-2735
ISSN: 1935-2727
EISSN: 1935-2735
DOI: 10.1371/journal.pntd.0000954
PMID: 21358811
Source: PLoS OA刊
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Mapping protein interactions between Dengue virus and its human and insect hosts

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