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Asthma Phenotype with Metabolic Dysfunction

Yonsei Medical Journal, 2022, 63(1), , pp.1-7 [Peer Reviewed Journal]

COPYRIGHT(C) KYOBO BOOK CENTRE ALL RIGHTS RESERVED ;Copyright: Yonsei University College of Medicine 2022. ;Copyright: Yonsei University College of Medicine 2022 2022 Yonsei University College of Medicine ;ISSN: 0513-5796 ;EISSN: 1976-2437 ;DOI: 10.3349/ymj.2022.63.1.1 ;PMID: 34913278

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  • Title:
    Asthma Phenotype with Metabolic Dysfunction
  • Author: 박중원
  • Subjects: Asthma ; Humans ; Inflammation ; Metabolic Syndrome ; Phenotype ; Review ; Vitamin D Deficiency - complications ; 의학일반
  • Is Part Of: Yonsei Medical Journal, 2022, 63(1), , pp.1-7
  • Description: Asthma is chronic eosinophilic bronchitis with the dominancy of T helper 2 (Th2) inflammation. However, patients with asthma and metabolic dysfunction have pathogenic and pathological differences from those with Th2 inflammation. Metabolic dysfunction, typically presented as metabolic syndrome, has several important clinical components including central obesity, insulin resistance or glucose intolerance, dyslipidemia, and vitamin D deficiency. Data from large epidemiological studies support the significance of these components in the control of asthma and their contribution to airway remodeling, suggesting the presence of an asthma phenotype with metabolic dysfunction. These components are quite interactive with each other, so it is difficult to reveal the individual role of each. It is well known that asthma is difficult to treat in patients with obesity, due in part to inadequate response to inhaled corticosteroids. Additionally, vitamin D deficiency and insulin resistance have been regarded as aggravating factors of asthma control and airway remodeling. Recent clinical and in vivo studies have revealed the specific mechanisms of these components, which may aggravate asthma control and airway remodeling. In this review article, I summarize the recent studies and unmet needs for patients with asthma and metabolic dysfunction.
  • Publisher: Korea (South): 연세대학교의과대학
  • Language: Korean;English
  • Identifier: ISSN: 0513-5796
    EISSN: 1976-2437
    DOI: 10.3349/ymj.2022.63.1.1
    PMID: 34913278
  • Source: KoreaMed (Open access)
    KoreaMed Synapse
    Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
    DOAJ Directory of Open Access Journals
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