Language:

ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1

Experimental and Molecular Medicine, 2021, 53(0), , pp.1-12 [Peer Reviewed Journal]

2021. The Author(s). ;The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2021 ;ISSN: 1226-3613 ;EISSN: 2092-6413 ;DOI: 10.1038/s12276-021-00701-z ;PMID: 34837016

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1
Author: Sonn, Seong Keun ; Seo, Seungwoon ; Yang, Jaemoon ; Oh, Ki Sook ; Chen, Hsiuchen ; Chan, David C ; Rhee, Kunsoo ; Lee, Kyung S ; Yang, Young ; Oh, Goo Taeg
Subjects: Ablation ; Adipokines - genetics ; Adipokines - metabolism ; Alzheimer's disease ; Alzheimers disease ; Animals ; Apoptosis ; Cardiac muscle ; Cardiovascular diseases ; Cell death ; Cell Line ; Collagen ; Dynamins - metabolism ; Endoplasmic reticulum ; Endoplasmic Reticulum - metabolism ; Etiology ; Humans ; Male ; Metabolic disorders ; Metabolism ; Mice ; Mice, Knockout ; Mitochondria ; Mitochondrial Dynamics ; Neurodegeneration ; Neurodegenerative diseases ; Protein Binding ; Proteins ; Tumor necrosis factor ; 생화학
Is Part Of: Experimental and Molecular Medicine, 2021, 53(0), , pp.1-12
Description: C1q/TNF-related protein 1 (CTRP1) is a CTRP family member that has collagenous and globular C1q-like domains. The secreted form of CTRP1 is known to be associated with cardiovascular and metabolic diseases, but its cellular roles have not yet been elucidated. Here, we showed that cytosolic CTRP1 localizes to the endoplasmic reticulum (ER) membrane and that knockout or depletion of CTRP1 leads to mitochondrial fission defects, as demonstrated by mitochondrial elongation. Mitochondrial fission events are known to occur through an interaction between mitochondria and the ER, but we do not know whether the ER and/or its associated proteins participate directly in the entire mitochondrial fission event. Interestingly, we herein showed that ablation of CTRP1 suppresses the recruitment of DRP1 to mitochondria and provided evidence suggesting that the ER-mitochondrion interaction is required for the proper regulation of mitochondrial morphology. We further report that CTRP1 inactivation-induced mitochondrial fission defects induce apoptotic resistance and neuronal degeneration, which are also associated with ablation of DRP1. These results demonstrate for the first time that cytosolic CTRP1 is an ER transmembrane protein that acts as a key regulator of mitochondrial fission, providing new insight into the etiology of metabolic and neurodegenerative disorders.
Publisher: United States: Springer Nature B.V
Language: English
Identifier: ISSN: 1226-3613
EISSN: 2092-6413
DOI: 10.1038/s12276-021-00701-z
PMID: 34837016
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
Alma/SFX Local Collection
Nature Free
KoreaMed Open Access
ProQuest Central
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1

Searching Remote Databases, Please Wait