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The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death

Experimental and Molecular Medicine, 2021, 53(0), , pp.1-9 [Peer Reviewed Journal]

The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2021 ;ISSN: 1226-3613 ;EISSN: 2092-6413 ;DOI: 10.1038/s12276-021-00600-3 ;PMID: 33854187

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Title:
The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death
Author: Nah, Jihoon ; Zablocki, Daniela ; Sadoshima, Junichi
Subjects: 1-Phosphatidylinositol 3-kinase ; Aging ; Animals ; Apoptosis ; Autophagy ; Autophagy - genetics ; Autophagy-Related Proteins - genetics ; Autophagy-Related Proteins - metabolism ; Biomarkers ; Cardiac muscle ; Cardiovascular disease ; Cell Death ; Coronary artery disease ; Disease Management ; Disease Susceptibility ; Drug development ; Endocytosis ; Heart ; Heart - physiology ; Heart diseases ; Homeostasis ; Humans ; Inflammation ; Metabolic disorders ; Molecular Targeted Therapy ; Myocardium - metabolism ; Phagocytosis ; Review ; Signal Transduction ; Therapeutic applications ; Therapeutic targets ; 생화학
Is Part Of: Experimental and Molecular Medicine, 2021, 53(0), , pp.1-9
Description: Autophagy contributes to the maintenance of cardiac homeostasis. The level of autophagy is dynamically altered in heart disease. Although autophagy is a promising therapeutic target, only a few selective autophagy activator candidates have been reported thus far. Rubicon is one of the few endogenous negative regulators of autophagy and a potential target for autophagy-inducing therapeutics. Rubicon was initially identified as a component of the Class III PI3K complex, and it has multiple functions, not only in canonical autophagy but also in endosomal trafficking and inflammatory responses. This review summarizes the molecular action of Rubicon in canonical and noncanonical autophagy. We discuss the roles of Rubicon in cardiac stress and the therapeutic potential of Rubicon in cardiac diseases through its modulation of autophagy.
Publisher: United States: Springer Nature B.V
Language: English
Identifier: ISSN: 1226-3613
EISSN: 2092-6413
DOI: 10.1038/s12276-021-00600-3
PMID: 33854187
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection
Nature Free
KoreaMed Open Access
ProQuest Central
DOAJ Directory of Open Access Journals

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The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death

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