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β-hydroxybutyrate and its metabolic effects on age-associated pathology

Experimental and Molecular Medicine, 2020, 52(0), , pp.1-8 [Peer Reviewed Journal]

The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2020. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2020 ;ISSN: 1226-3613 ;EISSN: 2092-6413 ;DOI: 10.1038/s12276-020-0415-z ;PMID: 32269287

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  • Title:
    β-hydroxybutyrate and its metabolic effects on age-associated pathology
  • Author: Han, Young-Min ; Ramprasath, Tharmarajan ; Zou, Ming-Hui
  • Subjects: Age ; Aging ; By products ; Cardiovascular diseases ; Cell membranes ; Clinical trials ; Dietary restrictions ; Fatty acids ; High fat diet ; Ketogenesis ; Ketone bodies ; Ketones ; Low carbohydrate diet ; Metabolism ; Metabolites ; Molecular modelling ; Neurodegenerative diseases ; Review ; 생화학
  • Is Part Of: Experimental and Molecular Medicine, 2020, 52(0), , pp.1-8
  • Description: Aging is a universal process that renders individuals vulnerable to many diseases. Although this process is irreversible, dietary modulation and caloric restriction are often considered to have antiaging effects. Dietary modulation can increase and maintain circulating ketone bodies, especially β-hydroxybutyrate (β-HB), which is one of the most abundant ketone bodies in human circulation. Increased β-HB has been reported to prevent or improve the symptoms of various age-associated diseases. Indeed, numerous studies have reported that a ketogenic diet or ketone ester administration alleviates symptoms of neurodegenerative diseases, cardiovascular diseases, and cancers. Considering the potential of β-HB and the intriguing data emerging from in vivo and in vitro experiments as well as clinical trials, this therapeutic area is worthy of attention. In this review, we highlight studies that focus on the identified targets of β-HB and the cellular signals regulated by β-HB with respect to alleviation of age-associated ailments.
  • Publisher: United States: Springer Nature B.V
  • Language: English
  • Identifier: ISSN: 1226-3613
    EISSN: 2092-6413
    DOI: 10.1038/s12276-020-0415-z
    PMID: 32269287
  • Source: Nature Open Access
    GFMER Free Medical Journals
    PubMed Central
    Alma/SFX Local Collection
    KoreaMed Open Access
    ProQuest Central
    DOAJ Directory of Open Access Journals
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