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The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies

Experimental and Molecular Medicine, 2020, 52(0), , pp.1-11 [Peer Reviewed Journal]

The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2020. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2020 ;ISSN: 1226-3613 ;EISSN: 2092-6413 ;DOI: 10.1038/s12276-020-0408-y ;PMID: 32788658

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  • Title:
    The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies
  • Author: Kang, Donghyun ; Lee, Jeeyeon ; Wu, Cuiyan ; Guo, Xiong ; Lee, Byeong Jae ; Chun, Jang-Soo ; Kim, Jin-Hong
  • Subjects: Antioxidants ; Arthritis ; Cardiovascular diseases ; Cartilage ; Cartilage diseases ; Disease ; Homeostasis ; Joint diseases ; Liver cancer ; Liver diseases ; Metabolism ; Osteoarthritis ; Oxidative stress ; Review ; Selenium ; Selenoproteins ; Supplementation ; Thyroid ; Thyroid gland ; Thyroid hormones ; Trace elements ; 생화학
  • Is Part Of: Experimental and Molecular Medicine, 2020, 52(0), , pp.1-11
  • Description: As an essential nutrient and trace element, selenium is required for living organisms and its beneficial roles in human health have been well recognized. The role of selenium is mainly played through selenoproteins synthesized by the selenium metabolic system. Selenoproteins have a wide range of cellular functions including regulation of selenium transport, thyroid hormones, immunity, and redox homeostasis. Selenium deficiency contributes to various diseases, such as cardiovascular disease, cancer, liver disease, and arthropathy-Kashin-Beck disease (KBD) and osteoarthritis (OA). A skeletal developmental disorder, KBD has been reported in low-selenium areas of China, North Korea, and the Siberian region of Russia, and can be alleviated by selenium supplementation. OA, the most common form of arthritis, is a degenerative disease caused by an imbalance in matrix metabolism and is characterized by cartilage destruction. Oxidative stress serves as a major cause of the initiation of OA pathogenesis. Selenium deficiency and dysregulation of selenoproteins are associated with impairments to redox homeostasis in cartilage. We review the recently explored roles of selenium metabolism and selenoproteins in cartilage with an emphasis on two arthropathies, KBD and OA. Moreover, we discuss the potential of therapeutic strategies targeting the biological functions of selenium and selenoproteins for OA treatment.
  • Publisher: United States: Springer Nature B.V
  • Language: English
  • Identifier: ISSN: 1226-3613
    EISSN: 2092-6413
    DOI: 10.1038/s12276-020-0408-y
    PMID: 32788658
  • Source: Nature Open Access
    GFMER Free Medical Journals
    PubMed Central
    Alma/SFX Local Collection
    KoreaMed Open Access
    ProQuest Central
    DOAJ Directory of Open Access Journals
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