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Gα12/13 signaling in metabolic diseases

Experimental and Molecular Medicine, 2020, 52(0), , pp.1-15 [Peer Reviewed Journal]

The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2020. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2020 ;ISSN: 1226-3613 ;EISSN: 2092-6413 ;DOI: 10.1038/s12276-020-0454-5 ;PMID: 32576930

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  • Title:
    Gα12/13 signaling in metabolic diseases
  • Author: Yang, Yoon Mee ; Kuen, Da-Sol ; Chung, Yeonseok ; Kurose, Hitoshi ; Kim, Sang Geon
  • Subjects: Cardiovascular diseases ; Diabetes mellitus ; Energy balance ; Energy metabolism ; Fibrosis ; G protein-coupled receptors ; Glucose metabolism ; Homeostasis ; Immunosuppressive agents ; Liver diseases ; Metabolic disorders ; Muscles ; Phenotypes ; Proteins ; Review ; Reviews ; 생화학
  • Is Part Of: Experimental and Molecular Medicine, 2020, 52(0), , pp.1-15
  • Description: As the key governors of diverse physiological processes, G protein-coupled receptors (GPCRs) have drawn attention as primary targets for several diseases, including diabetes and cardiovascular disease. Heterotrimeric G proteins converge signals from ~800 members of the GPCR family. Among the members of the G protein α family, the Gα12 family members comprising Gα12 and Gα13 have been referred to as gep oncogenes. Gα12/13 levels are altered in metabolic organs, including the liver and muscles, in metabolic diseases. The roles of Gα12/13 in metabolic diseases have been investigated. In this review, we highlight findings demonstrating Gα12/13 amplifying or dampening regulators of phenotype changes. We discuss the molecular basis of G protein biology in the context of posttranslational modifications to heterotrimeric G proteins and the cell signaling axis. We also highlight findings providing insights into the organ-specific, metabolic and pathological roles of G proteins in changes associated with specific cells, energy homeostasis, glucose metabolism, liver fibrosis and the immune and cardiovascular systems. This review summarizes the currently available knowledge on the importance of Gα12/13 in the physiology and pathogenesis of metabolic diseases, which is presented according to the basic understanding of their metabolic actions and underlying cellular and molecular bases. Metabolic diseases: Going after G proteins Understanding the activities of two members of a vital category of proteins called G proteins, which initiate metabolic changes when signaling molecules bind to cells, could lead to new therapies for many diseases. Researchers in South Korea and Japan, led by Sang Geon Kim at Seoul National University, review the significance of the Gα12 and Gα13 proteins in diseases characterised by significant changes in metabolism, including liver conditions and disorders of the cardiovascular and immune systems. Specific roles for the proteins have been identified by a variety of methods, including studying the effect of disabling the genes that code for them in mice. Recent insights suggest that drugs interfering with the activity of these Gα proteins might help treat many conditions in which the molecular signalling networks involving the proteins are disrupted.
  • Publisher: Seoul: Springer Nature B.V
  • Language: English
  • Identifier: ISSN: 1226-3613
    EISSN: 2092-6413
    DOI: 10.1038/s12276-020-0454-5
    PMID: 32576930
  • Source: Nature OA刊
    GFMER Free Medical Journals
    PubMed Central
    Alma/SFX Local Collection
    KoreaMed Open Access
    ProQuest Central
    DOAJ Directory of Open Access Journals
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