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Protein disulfide isomerase in cardiovascular disease

Experimental and Molecular Medicine, 2020, 52(0), , pp.1-10 [Peer Reviewed Journal]

The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2020. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2020 ;ISSN: 1226-3613 ;EISSN: 2092-6413 ;DOI: 10.1038/s12276-020-0401-5 ;PMID: 32203104

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  • Title:
    Protein disulfide isomerase in cardiovascular disease
  • Author: Xiong, Bei ; Jha, Vishwanath ; Min, Jeong-Ki ; Cho, Jaehyung
  • Subjects: Biological activity ; Cardiovascular disease ; Cardiovascular diseases ; Coronary artery disease ; Enzymes ; Heart diseases ; Myocardial infarction ; Protein disulfide-isomerase ; Proteins ; Review ; Thrombosis ; 생화학
  • Is Part Of: Experimental and Molecular Medicine, 2020, 52(0), , pp.1-10
  • Description: Protein disulfide isomerase (PDI) participates in the pathogenesis of numerous diseases. Increasing evidence indicates that intravascular cell-derived PDI plays an important role in the initiation and progression of cardiovascular diseases, including thrombosis and vascular inflammation. Recent studies with PDI conditional knockout mice have advanced our understanding of the function of cell-specific PDI in disease processes. Furthermore, the identification and development of novel small-molecule PDI inhibitors has led into a new era of PDI research that transitioned from the bench to bedside. In this review, we will discuss recent findings on the regulatory role of PDI in cardiovascular disease.
  • Publisher: United States: Springer Nature B.V
  • Language: English
  • Identifier: ISSN: 1226-3613
    EISSN: 2092-6413
    DOI: 10.1038/s12276-020-0401-5
    PMID: 32203104
  • Source: GFMER Free Medical Journals
    PubMed Central
    Alma/SFX Local Collection
    Nature Free
    KoreaMed Open Access
    ProQuest Central
    DOAJ Directory of Open Access Journals
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