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Accumulated endogenous NOS inhibitors and decreased NOS activity for the impaired trigonal relaxation with ischemia

Journal of Pharmacological Sciences, 2003, Vol.91 (suppl.2), p.270-270 [Peer Reviewed Journal]

ISSN: 1347-8613 ;EISSN: 1347-8648

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  • Title:
    Accumulated endogenous NOS inhibitors and decreased NOS activity for the impaired trigonal relaxation with ischemia
  • Author: Hitoshi Masuda ; Masataka Yano ; Kazunori Kihara ; Moritaka Goto ; Hiroshi Azuma
  • Is Part Of: Journal of Pharmacological Sciences, 2003, Vol.91 (suppl.2), p.270-270
  • Description: Objective: We examined whether endogenous NOS inhibitors are involved in the impaired trigonal relaxation with ischemia. Methods: Rabbits were divided into control and ischemia (IS) groups. Two weeks after partial vessel occlusion, strips of trigone were processed for determination of endogenous methylarginines and L- arginine by automated HPLC, NOS activity and NO- mediated functional responses to electrical field stimulation (EFS) between two groups. Results: Neurogenic and NO-mediated relaxations in the trigone, but not sodium nitroprusside (SNP)-induced one were significantly impaired following ischemia. The Ca2+- dependent NOS activity and the basal and stimulated cyclic GMP productions with EFS were significantly decreased following ischemia. The contents of L-NMMA and ADMA but not L-arginine and SDMA were increased in the trigone following ischemia. Authentic L-NMMA and ADMA but not SDMA concentration-dependently inhibited neurogenic relaxations without affecting the relaxation produced by SNP in the control tissue. Excess L-arginine abolished the inhibition with L-NMMA and ADMA. Conclusions: These results suggest that the impaired NO-mediated trigonal relaxations following ischemia is closely related to the decreased NOS activity and the increased accumulation of L-NMMA and ADMA.
  • Publisher: The Japanese Pharmacological Society
  • Language: Japanese
  • Identifier: ISSN: 1347-8613
    EISSN: 1347-8648
  • Source: Geneva Foundation Free Medical Journals
    ROAD: Directory of Open Access Scholarly Resources
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