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The differential effects of anemia on mortality in young and elderly end-stage renal disease patients

Kidney research and clinical practice, 2020-06, Vol.39 (2), p.192-201 [Peer Reviewed Journal]

COPYRIGHT(C) KYOBO BOOK CENTRE ALL RIGHTS RESERVED ;ISSN: 2211-9132

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  • Title:
    The differential effects of anemia on mortality in young and elderly end-stage renal disease patients
  • Author: Eun Jeong Ko ; Yong Kyun Kim ; Jang-hee Cho ; Yon Su Kim ; Shin-wook Kang ; Nam-ho Kim ; Yong-lim Kim ; Chul Woo Yang ; Byung Ha Chung
  • Subjects: Aged ; Cardiovascular diseases ; Dialysis ; Hemoglobin target ; Mortality
  • Is Part Of: Kidney research and clinical practice, 2020-06, Vol.39 (2), p.192-201
  • Description: Background: The aim of this study was to compare the effect of anemia on clinical outcomes according to age in patients with end-stage renal disease (ESRD). Methods: A total of 3,409 patients from the Clinical Research Center for ESRD were included and divided into three groups by age: age < 40 (n = 488), 40 ≤ age < 60 (n = 1,650), and age ≥ 60 (n = 1,271). We compared overall and cardiovascular mortality, and all-cause and cardiovascular hospitalization according to mean hemoglobin (Hb) concentration. Results: Among participants ≥ 60 years of age, the Hb < 10 g/dL group had greater all-cause mortality (adjusted hazard ratio [HR], 2.098; 95% confidence interval [CI], 1.567-2.808; P < 0.001) than the 10 ≤ Hb < 12 g/dL group, whereas among participants < 40 years of age, the Hb ≥ 12 g/dL group had greater mortality than the 10 ≤ Hb < 12 g/dL group. Moreover, in participants ≥ 60 years of age, the HR for all-cause hospitalization for the Hb < 10 g/dL group was significantly greater than that of the 10 ≤ Hb < 12 g/dL group (HR, 1.472; 95% CI, 1.057-2.051; P = 0.022), whereas it was significantly lower in the Hb ≥ 12 g/dL group (HR, 0.544; 95% CI, 0.362-0.820; P = 0.004) However, among participants < 40 years of age, the incidence of all-cause hospitalization did not differ according to the Hb concentration (HR, 1.273; 95% CI, 0.814-1.991; P = 0.290 for the Hb < 10 g/dL group; reference, 10 ≤ Hb < 12 g/dL; HR, 0.787; 95% CI, 0.439-1.410; P = 0.265 for Hb ≥ 12 g/dL group). Conclusion: The impact of anemia on mortality was more significant in elderly ESRD patients. Strict monitoring and management of anemia should be required for elderly ESRD patients.
  • Publisher: 대한신장학회
  • Language: Korean
  • Identifier: ISSN: 2211-9132
  • Source: PubMed Central
    DOAJ Directory of Open Access Journals
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