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Strong reproductive isolation between humans and Neanderthals inferred from observed patterns of introgression

Proceedings of the National Academy of Sciences - PNAS, 2011-09, Vol.108 (37), p.15129-15134 [Tạp chí có phản biện]

Copyright National Academy of Sciences Sep 13, 2011 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.1107450108 ;PMID: 21911389

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Nhan đề:
Strong reproductive isolation between humans and Neanderthals inferred from observed patterns of introgression
Tác giả: Currat, Mathias ; Excoffier, Laurent
Chủ đề: Admixtures ; Ancestry ; Animals ; Asian Continental Ancestry Group ; Asians ; Biological Sciences ; China ; Computer Simulation ; Consanguinity ; Demography ; European Continental Ancestry Group ; Europeans ; Evolution ; Evolutionary genetics ; France ; gene flow ; Genetic hybridization ; genome ; Hominidae - physiology ; Hominids ; Human genetics ; Humans ; Hybridity ; Hybridization, Genetic ; hybrids ; introgression ; Mitochondrial DNA ; Neanderthals ; Reproduction ; Reproduction - physiology ; reproductive isolation
Là 1 phần của: Proceedings of the National Academy of Sciences - PNAS, 2011-09, Vol.108 (37), p.15129-15134
Mô tả: Recent studies have revealed that 2–3% of the genome of non-Africans might come from Neanderthals, suggesting a more complex scenario of modern human evolution than previously anticipated. In this paper, we use a model of admixture during a spatial expansion to study the hybridization of Neanderthals with modern humans during their spread out of Africa. We find that observed low levels of Neanderthal ancestry in Eurasians are compatible with a very low rate of interbreeding (<2%), potentially attributable to a very strong avoidance of interspecific matings, a low fitness of hybrids, or both. These results suggesting the presence of very effective barriers to gene flow between the two species are robust to uncertainties about the exact demography of the Paleolithic populations, and they are also found to be compatible with the observed lack of mtDNA introgression. Our model additionally suggests that similarly low levels of introgression in Europe and Asia may result from distinct admixture events having occurred beyond the Middle East, after the split of Europeans and Asians. This hypothesis could be tested because it predicts that different components of Neanderthal ancestry should be present in Europeans and in Asians.
Nơi xuất bản: United States: National Academy of Sciences
Ngôn ngữ: English
Số nhận dạng: ISSN: 0027-8424
EISSN: 1091-6490
DOI: 10.1073/pnas.1107450108
PMID: 21911389
Nguồn: GFMER Free Medical Journals
MEDLINE
PubMed Central

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Strong reproductive isolation between humans and Neanderthals inferred from observed patterns of introgression

Copyright National Academy of Sciences Sep 13, 2011 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.1107450108 ;PMID: 21911389

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