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Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (37), p.14157-14162 [Peer Reviewed Journal]

Copyright 2008 The National Academy of Sciences of the United States of America ;Copyright National Academy of Sciences Sep 16, 2008 ;2008 by The National Academy of Sciences of the USA ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.0806658105 ;PMID: 18780780

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Title:
Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain
Author: Faulkner, Regina L ; Jang, Mi-Hyeon ; Liu, Xiao-Bo ; Duan, Xin ; Sailor, Kurt A ; Kim, Ju Young ; Ge, Shaoyu ; Jones, Edward G ; Ming, Guo-li ; Song, Hongjun ; Cheng, Hwai-Jong
Subjects: Adults ; Aging - physiology ; Animals ; Animals, Newborn ; Axons ; Biological Sciences ; Brain ; Cells ; Dendrites ; Dendritic spines ; Developmental biology ; Female ; Hippocampus ; Mammals ; Mental disorders ; Mice ; Mice, Inbred C57BL ; Microscopy, Electron ; Mossy Fibers, Hippocampal - growth & development ; Mossy Fibers, Hippocampal - ultrastructure ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; Neurons ; Neurons - cytology ; Neurons - metabolism ; RNA Interference ; Schizophrenia ; Synapses ; Synapses - physiology ; Synapses - ultrastructure
Is Part Of: Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (37), p.14157-14162
Description: New neurons are continuously generated in restricted regions of the adult mammalian brain. Although these adult-born neurons have been shown to receive synaptic inputs, little is known about their synaptic outputs. Using retrovirus-mediated birth-dating and labeling in combination with serial section electron microscopic reconstruction, we report that mossy fiber en passant boutons of adult-born dentate granule cells form initial synaptic contacts with CA3 pyramidal cells within 2 weeks after their birth and reach morphologic maturity within 8 weeks in the adult hippocampus. Knockdown of Disrupted-in-Schizophrenia-1 (DISC1) in newborn granule cells leads to defects in axonal targeting and development of synaptic outputs in the adult brain. Together with previous reports of synaptic inputs, these results demonstrate that adult-born neurons are fully integrated into the existing neuronal circuitry. Our results also indicate a role for DISC1 in presynaptic development and may have implications for the etiology of schizophrenia and related mental disorders.
Publisher: United States: National Academy of Sciences
Language: English
Identifier: ISSN: 0027-8424
EISSN: 1091-6490
DOI: 10.1073/pnas.0806658105
PMID: 18780780
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central

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Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain

Copyright 2008 The National Academy of Sciences of the United States of America ;Copyright National Academy of Sciences Sep 16, 2008 ;2008 by The National Academy of Sciences of the USA ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.0806658105 ;PMID: 18780780

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