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Klp10A modulates the localization of centriole-associated proteins during Drosophila male gametogenesis

Cell Cycle, 2016, Vol.15 (24), p.3432-3441

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Title:
Klp10A modulates the localization of centriole-associated proteins during Drosophila male gametogenesis
Author: Gottardo, Marco ; Callaini, Giuliano ; Riparbelli, Maria Giovanna
Subjects: centriole-associated proteins ; centrioles ; Drosophila ; male gametogenesis
Is Part Of: Cell Cycle, 2016, Vol.15 (24), p.3432-3441
Description: Mutations in Klp10A, a microtubule-depolymerising Kinesin-13, lead to overly long centrioles in Drosophila male germ cells. We demonstrated that the loss of Klp10A modifies the distribution of typical proteins involved in centriole assembly and function. In the absence of Klp10A the distribution of Drosophila pericentrin-like protein (Dplp), Sas-4 and Sak/Plk4 that are restricted in control testes to the proximal end of the centriole increase along the centriole length. Remarkably, the cartwheel is lacking or it appears abnormal in mutant centrioles, suggesting that this structure may spatially delimit protein localization. Moreover, the parent centrioles that in control cells have the same dimensions grow at different rates in mutant testes with the mother centrioles longer than the daughters. Daughter centrioles have often an ectopic position with respect to the proximal end of the mothers and failed to recruit Dplp.
Publisher: Taylor & Francis
Language: English
Identifier: ISSN: 1538-4101
EISSN: 1551-4005
DOI: 10.1080/15384101.2016.1248005
Source: PubMed Central

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