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Challenges and directions in studying cell-cell communication by extracellular vesicles

Nature reviews. Molecular cell biology, 2022-05, Vol.23 (5), p.369-382 [Peer Reviewed Journal]

2022. Springer Nature Limited. ;Springer Nature Limited 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 1471-0072 ;EISSN: 1471-0080 ;DOI: 10.1038/s41580-022-00460-3 ;PMID: 35260831

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Title:
Challenges and directions in studying cell-cell communication by extracellular vesicles
Author: van Niel, Guillaume ; Carter, David R F ; Clayton, Aled ; Lambert, Daniel W ; Raposo, Graça ; Vader, Pieter
Subjects: Biological Transport ; Biomarkers ; Biomarkers - metabolism ; Cell Communication ; Cell interactions ; Chemical compounds ; Communication ; Drug delivery ; Drug Delivery Systems ; Extracellular vesicles ; Extracellular Vesicles - metabolism ; Life Sciences ; Molecular modelling ; Pharmacology ; Questions ; Vesicles
Is Part Of: Nature reviews. Molecular cell biology, 2022-05, Vol.23 (5), p.369-382
Description: Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. They have important roles in numerous physiological and pathological processes, and show considerable promise as novel biomarkers of disease, as therapeutic agents and as drug delivery vehicles. Intriguingly, however, understanding of the cellular and molecular mechanisms that govern the many observed functions of EVs remains far from comprehensive, at least partly due to technical challenges in working with these small messengers. Here, we highlight areas of consensus as well as contentious issues in our understanding of the intracellular and intercellular journey of EVs: from biogenesis, release and dynamics in the extracellular space, to interaction with and uptake by recipient cells. We define knowledge gaps, identify key questions and challenges, and make recommendations on how to address these.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1471-0072
EISSN: 1471-0080
DOI: 10.1038/s41580-022-00460-3
PMID: 35260831
Source: MEDLINE
ProQuest Central

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Challenges and directions in studying cell-cell communication by extracellular vesicles

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