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Acquisition of Class C β-Lactamase PAC-1 by Sequence Type 644 Strains of Pseudomonas aeruginosa

Antimicrobial agents and chemotherapy, 2019-12, Vol.63 (12), p.1469-1472 [Peer Reviewed Journal]

Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0066-4804 ;EISSN: 1098-6596 ;DOI: 10.1128/AAC.01375-19 ;PMID: 31527025

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  • Title:
    Acquisition of Class C β-Lactamase PAC-1 by Sequence Type 644 Strains of Pseudomonas aeruginosa
  • Author: Bour, Maxime ; Fournier, Damien ; Jové, Thomas ; Pouzol, Armelle ; Miltgen, Guillaume ; Janvier, Frédéric ; Jeannot, Katy ; Plésiat, Patrick
  • Subjects: Environmental Sciences
  • Is Part Of: Antimicrobial agents and chemotherapy, 2019-12, Vol.63 (12), p.1469-1472
  • Description: Four sequence type 664 (ST664) (serotype O:5) strains of Pseudomonas aeruginosa that were highly resistant to antibiotics, including ceftolozane-tazobactam and ceftazidime-avibactam, but were susceptible to colistin were found to harbor the gene encoding the rare class C β-lactamase PAC-1 on a chromosomally located Tn 1721 -like transposon. The bla PAC-1 gene was associated with the 16S rRNA methylase determinant rmtF2 , which confers pan-aminoglycoside resistance.
  • Publisher: American Society for Microbiology
  • Language: English
  • Identifier: ISSN: 0066-4804
    EISSN: 1098-6596
    DOI: 10.1128/AAC.01375-19
    PMID: 31527025
  • Source: Open Access: PubMed Central
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