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Benzylidenemalononitrile compounds as activators of cell resistance to oxidative stress and modulators of multiple signaling pathways. A structure-activity relationship study

Biochemical pharmacology, 2011-09, Vol.82 (5), p.535 [Peer Reviewed Journal]

Copyright © 2011 Elsevier Inc. All rights reserved. ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0006-2952 ;EISSN: 1873-2968 ;DOI: 10.1016/j.bcp.2011.05.028 ;PMID: 21669191

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Title:
Benzylidenemalononitrile compounds as activators of cell resistance to oxidative stress and modulators of multiple signaling pathways. A structure-activity relationship study
Author: Turpaev, Kyril ; Ermolenko, Mikhail ; Cresteil, Thierry ; Drapier, Jean Claude
Subjects: Benzylidene Compounds - metabolism ; Benzylidene Compounds - pharmacology ; Chemical Sciences ; Chromatography, Liquid ; Glutathione - metabolism ; Heme Oxygenase-1 - genetics ; Heme Oxygenase-1 - metabolism ; Humans ; Life Sciences ; Nitriles - metabolism ; Nitriles - pharmacology ; Organic chemistry ; Oxidative Stress ; Pharmaceutical sciences ; Pharmacology ; RNA, Messenger - analysis ; Signal Transduction - drug effects ; Signal Transduction - physiology ; Spectrometry, Mass, Electrospray Ionization ; Structure-Activity Relationship ; Tyrphostins - pharmacology ; U937 Cells
Is Part Of: Biochemical pharmacology, 2011-09, Vol.82 (5), p.535
Description: Benzylidenemalononitrile (BMN) tyrphostins are well known as potent tyrosine kinase inhibitors. Moreover, in recent years it has been recognized that members of the tyrphostin family possess additional biological activities independent of their ability to inhibit protein tyrosine kinases. In this study, we examined the relationship between the structure of 49 BMNs and related compounds, and their capacity to induce heme oxygenase 1 (HO-1) gene expression in U937 human monocytic cells, to activate upstream signaling pathways and to protect cells against menadione-induced oxidative stress. It was found that the electron-withdrawing (NO(2), CN, halogen) groups in BMN molecules and double meta-MeO substituents increased the HO-1 gene induction, while the electron-donating groups in ortho/para position (OH, MeO and N-morpholino) significantly decreased it. The magnitude of activation of c-Jun, Nrf2, p38 MAPK, and p70S6K correlated with specific substitution patterns in the BMN structure. BMN-dependent maximal up-regulation of HO-1 required parallel increase in Nrf2 and phospho-c-Jun cellular levels. Liquid chromatography mass spectrometry (LC-MS) analysis revealed that BMNs can generate conjugates with one or two glutathione equivalent(s). This study supports the hypothesis that BMNs induce the expression of protective genes by alkylating sensitive cysteine residues of regulatory factors.
Publisher: England: Elsevier
Language: English
Identifier: ISSN: 0006-2952
EISSN: 1873-2968
DOI: 10.1016/j.bcp.2011.05.028
PMID: 21669191
Source: Hyper Article en Ligne (HAL) (Open Access)

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Benzylidenemalononitrile compounds as activators of cell resistance to oxidative stress and modulators of multiple signaling pathways. A structure-activity relationship study

Copyright © 2011 Elsevier Inc. All rights reserved. ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0006-2952 ;EISSN: 1873-2968 ;DOI: 10.1016/j.bcp.2011.05.028 ;PMID: 21669191

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