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Nanoparticles as vehicles for delivery of photodynamic therapy agents

Trends in biotechnology (Regular ed.), 2008-11, Vol.26 (11), p.612-621 [Peer Reviewed Journal]

Elsevier Ltd ;2008 Elsevier Ltd ;2009 INIST-CNRS ;Copyright Elsevier Limited Nov 2008 ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0167-7799 ;EISSN: 1879-3096 ;DOI: 10.1016/j.tibtech.2008.07.007 ;PMID: 18804298 ;CODEN: TRBIDM

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Title:
Nanoparticles as vehicles for delivery of photodynamic therapy agents
Author: Bechet, Denise ; Couleaud, Pierre ; Frochot, Céline ; Viriot, Marie-Laure ; Guillemin, François ; Barberi-Heyob, Muriel
Subjects: Acids ; Apoptosis ; Biochemistry, Molecular Biology ; Biodegradation ; Biodegradation, Environmental ; Biological and medical sciences ; Biophysics ; Biotechnology ; Contrast agents ; Efficiency ; Experiments ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Health. Pharmaceutical industry ; Humans ; Industrial applications and implications. Economical aspects ; Internal Medicine ; Life Sciences ; Light ; Medical sciences ; Miscellaneous ; Nanoparticles - chemistry ; Neoplasms - drug therapy ; Pharmaceutical technology. Pharmaceutical industry ; Pharmaceutical Vehicles - chemistry ; Pharmaceutical Vehicles - pharmacokinetics ; Pharmacology. Drug treatments ; Photochemotherapy - methods ; Photodynamic therapy ; Photosensitizing Agents - administration & dosage ; Photosensitizing Agents - therapeutic use ; Polymers ; Vehicles
Is Part Of: Trends in biotechnology (Regular ed.), 2008-11, Vol.26 (11), p.612-621
Description: Photodynamic therapy (PDT) in cancer treatment involves the uptake of a photosensitizer by cancer tissue followed by photoirradiation. The use of nanoparticles as carriers of photosensitizers is a very promising approach because these nanomaterials can satisfy all the requirements for an ideal PDT agent. This review describes and compares the different individual types of nanoparticles that are currently in use for PDT applications. Recent advances in the use of nanoparticles, including inorganic oxide-, metallic-, ceramic-, and biodegradable polymer-based nanomaterials as carriers of photosensitizing agents, are highlighted. We describe the nanoparticles in terms of stability, photocytotoxic efficiency, biodistribution and therapeutic efficiency. Finally, we summarize exciting new results concerning the improvement of the photophysical properties of nanoparticles by means of biphotonic absorption and upconversion.
Publisher: Cambridge, MA: Elsevier Ltd
Language: English
Identifier: ISSN: 0167-7799
EISSN: 1879-3096
DOI: 10.1016/j.tibtech.2008.07.007
PMID: 18804298
CODEN: TRBIDM
Source: MEDLINE
ProQuest Central

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Nanoparticles as vehicles for delivery of photodynamic therapy agents

Elsevier Ltd ;2008 Elsevier Ltd ;2009 INIST-CNRS ;Copyright Elsevier Limited Nov 2008 ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0167-7799 ;EISSN: 1879-3096 ;DOI: 10.1016/j.tibtech.2008.07.007 ;PMID: 18804298 ;CODEN: TRBIDM

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