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Poly butyl ether prolongs the repellent effect of N,N-diethyl-3-toluamide on the skin
PloS one, 2023-10, Vol.18 (10), p.e0292447
[Peer Reviewed Journal]
COPYRIGHT 2023 Public Library of Science ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0292447
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Title:
Poly butyl ether prolongs the repellent effect of N,N-diethyl-3-toluamide on the skin
Author:
Kawaguchi, Mayu
;
Matsumoto, Kana
;
Yoshitomi, Joji
;
Otake, Hiroko
;
Sato, Kanta
;
Taga, Atsushi
;
Sasabe, Tatsuji
;
Nobuhara, Kenji
;
Matsubara, Akira
;
Nagai, Noriaki
Subjects:
Instrument industry
;
Skin
Is Part Of:
PloS one, 2023-10, Vol.18 (10), p.e0292447
Description:
N,N-diethyl-meta-toluamide (DEET) is a widely used insect repellent, with minimal skin permeation and sustained repellent activity in the superficial layers of the skin. In this study, we prepared a 10% DEET formulation consisting of 40% ethanol with or without 2% poly(oxyethylene)/poly(oxypropylene) butyl ether (POE-POP), an amphiphilic random copolymer. Further, we demonstrated the effects of POE-POP on tensile stress (stickiness), hydrophobicity, skin retention, permeation, and repellent activity of DEET. Stickiness was measured in male ICR mice (7-week old), and skin retention and permeation were evaluated in male Wistar rats (7-week old). In addition, female Aedes albopictus were used to measure the repellent action of DEET. The addition of POE-POP did not affect stickiness, volatility, and degradability but decreased logP and increased viscosity of DEET. Next, we demonstrated the behavior of DEET formulations in the rat skin. POE-POP prolonged the retention of DEET in the superficial layers of the rat skin (skin surface and stratum corneum) and decreased the penetration of DEET into rat skin tissues (epithelium and dermis). The repellent effect of DEET was also enhanced by the addition of POE-POP. However, severe skin damage was not observed after repetitive treatment with DEET formulations containing POE-POP for one month (twice a day). In conclusion, we demonstrated that a 10% DEET formulation consisting of 40% ethanol and 2% POE-POP attenuated the skin penetration and prolonged the repellent action of DEET without causing stickiness and skin damage. We conclude that the combination of ethanol and POE-POP is useful as a safe and effective delivery system for the development of insect repellent formulations containing DEET.
Publisher:
Public Library of Science
Language:
English
Identifier:
ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0292447
Source:
Geneva Foundation Free Medical Journals at publisher websites
PLoS
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals
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