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Incidence of
Melanoma management, 2023-11, Vol.10 (1)
[Peer Reviewed Journal]
2023 The Authors ;ISSN: 2045-0885 ;EISSN: 2045-0893 ;DOI: 10.2217/mmt-2023-0005
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Title:
Incidence of
Subjects:
cutaneous melanoma
;
histological subtype
;
mutations
;
prognosis prediction
Is Part Of:
Melanoma management, 2023-11, Vol.10 (1)
Description:
This study aimed to investigate the incidence of mutation in cutaneous melanoma in the Ukrainian population with respect to clinical and histopathological data. This single-center retrospective cohort study enrolled 299 primary CM with known status assessed by RT-PCR. The overall mutation rate was 56.5% in CM and demonstrated a link with the younger age (p < 0.001), anatomical site (p < 0.001) and histological type of CM (p = 0.022). -positive CM possessed a slightly higher mitotic rate (p = 0.015) and Breslow thickness (p = 0.028) but did not relate to tumor-infiltrating lymphocytes. The high rate of mutations in CM patients in the Ukrainian cohort was associated with superficial spreading histology, higher depth of invasion and proliferation.
Publisher:
Future Medicine Ltd
Language:
English
Identifier:
ISSN: 2045-0885
EISSN: 2045-0893
DOI: 10.2217/mmt-2023-0005
Source:
Future Medicine (Open Access)
PubMed Central
DOAJ Directory of Open Access Journals
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