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Incidence of

Melanoma management, 2023-11, Vol.10 (1) [Peer Reviewed Journal]

2023 The Authors ;ISSN: 2045-0885 ;EISSN: 2045-0893 ;DOI: 10.2217/mmt-2023-0005

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  • Title:
    Incidence of
  • Subjects: cutaneous melanoma ; histological subtype ; mutations ; prognosis prediction
  • Is Part Of: Melanoma management, 2023-11, Vol.10 (1)
  • Description: This study aimed to investigate the incidence of mutation in cutaneous melanoma in the Ukrainian population with respect to clinical and histopathological data. This single-center retrospective cohort study enrolled 299 primary CM with known status assessed by RT-PCR. The overall mutation rate was 56.5% in CM and demonstrated a link with the younger age (p < 0.001), anatomical site (p < 0.001) and histological type of CM (p = 0.022). -positive CM possessed a slightly higher mitotic rate (p = 0.015) and Breslow thickness (p = 0.028) but did not relate to tumor-infiltrating lymphocytes. The high rate of mutations in CM patients in the Ukrainian cohort was associated with superficial spreading histology, higher depth of invasion and proliferation.
  • Publisher: Future Medicine Ltd
  • Language: English
  • Identifier: ISSN: 2045-0885
    EISSN: 2045-0893
    DOI: 10.2217/mmt-2023-0005
  • Source: Future Medicine (Open Access)
    PubMed Central
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