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PROCESS FOR PRODUCING 4,5-DIHYDRO-1H-PYRAZOLES AND INTERMEDIATES

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Title:
PROCESS FOR PRODUCING 4,5-DIHYDRO-1H-PYRAZOLES AND INTERMEDIATES
Author: BRUNET, Vincent ; PAVLOVIC, Drazen ; BROWN, Gareth ; MIX, Stefan ; GREEN, Jeremy
Subjects: APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY
Description: Described are processes for the manufacture of compounds containing a (S)-4,5-dihydro-1H-pyrazole ring. These processes include a chiral resolution step of an intermediate using selected chiral resolving agents. For example, the chiral resolving agents may be selected from (−)-quinine, (R)-phenethylamine, (S)-phenethylamine, (S)-1-naphthylethy lamine, (R)-(−)-2-amino-3-methyl-1-butanol, (−)-cinchonidine, (−)-spartein, (R)-1-naphthylethy lamine, D-arginine, L-lysine, (S)-(+)-2-pyrrolidinemethanol and(1R,2S)-(+)-cis-1-amino-2-indanol.
Creation Date: 2024
Language: English;French;German
Source: esp@cenet

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