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PH/reduction dual-response polymeric micelle as well as preparation method and application thereof

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Title:
PH/reduction dual-response polymeric micelle as well as preparation method and application thereof
Author: YIN LI ; WANG DELIN ; YANG CHUFEN ; YANG ZEXIONG ; ZHAO HAIQIAN
Subjects: CHEMISTRY ; COMPOSITIONS BASED THEREON ; HUMAN NECESSITIES ; HYGIENE ; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; THEIR PREPARATION OR CHEMICAL WORKING-UP
Description: The invention relates to the technical field of polymeric micelles, in particular to a pH/reduction dual-response polymeric micelle as well as a preparation method and application thereof. Wherein the structure of the pH/reduction dual-response polymer micelle comprises polyethylene glycol methyl ether methacrylate, epsilon-caprolactone, gamma-amino-epsilon-caprolactone and disulfide bonds, so that the polymer micelle can stably exist in a normal cell under a microenvironment condition after being loaded with an anti-cancer drug; the drug is rapidly released in the acidic and high glutathione environment in tumor cells, and the technical problem that the drug controlled release performance of polymer drug-loaded micelles in the prior art still needs to be improved is solved. 本申请涉及聚合物胶束技术领域，尤其涉及一种pH/还原双重响应聚合物胶束及其制备方法与应用。其中，pH/还原双重响应聚合物胶束的结构包括聚乙二醇甲基醚甲基丙烯酸酯、ε-己内酯、γ-氨基-ε-己内酯以及二硫键，使得聚合物胶束负载抗癌药物后，可在正常细胞内微环境条件中稳定存在，在肿瘤细胞中的酸性以及高谷胱甘肽环境下迅速释放药物，解决了现有技术中聚合物载药胶束药物控释的性能还有待提高的技术问题。
Creation Date: 2022
Language: Chinese;English
Source: esp@cenet

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PH/reduction dual-response polymeric micelle as well as preparation method and application thereof

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