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Peripheral microangiopathy in precapillary pulmonary hypertension: a nailfold video capillaroscopy prospective study

Respiratory research, 2021-01, Vol.22 (1), p.27-27, Article 27 [Peer Reviewed Journal]

COPYRIGHT 2021 BioMed Central Ltd. ;2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2021 ;ISSN: 1465-993X ;ISSN: 1465-9921 ;EISSN: 1465-993X ;DOI: 10.1186/s12931-021-01622-1 ;PMID: 33478514

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Title:
Peripheral microangiopathy in precapillary pulmonary hypertension: a nailfold video capillaroscopy prospective study
Author: Arvanitaki, Alexandra ; Giannakoulas, George ; Triantafyllidou, Eva ; Feloukidis, Christos ; Boutou, Afroditi K ; Garyfallos, Alexandros ; Karvounis, Haralambos ; Dimitroulas, Theodoros
Subjects: Abnormalities ; Adult ; Aged ; Capillaries - diagnostic imaging ; Capillaries - physiology ; Case-Control Studies ; Chronic thromboembolic pulmonary hypertension ; Complications and side effects ; Continuity (mathematics) ; Diagnosis ; Digital imaging ; Edema ; Familial Primary Pulmonary Hypertension - diagnostic imaging ; Familial Primary Pulmonary Hypertension - physiopathology ; Female ; Humans ; Hypertension ; Hypertension, Pulmonary - diagnostic imaging ; Hypertension, Pulmonary - physiopathology ; Idiopathic pulmonary hypertension ; Laboratories ; Lung diseases ; Male ; Microcirculation - physiology ; Microcirculation disorders ; Microscopic Angioscopy - methods ; Microvasculature ; Middle Aged ; Morphology ; Nailfold video-capillaroscopy ; Peripheral microangiopathy ; Peripheral vascular diseases ; Precapillary pulmonary hypertension ; Prospective Studies ; Pulmonary arteries ; Pulmonary Embolism - diagnostic imaging ; Pulmonary Embolism - physiopathology ; Pulmonary hypertension ; Risk factors ; Software ; Task forces ; Thromboembolism ; Variance analysis ; Vascular diseases
Is Part Of: Respiratory research, 2021-01, Vol.22 (1), p.27-27, Article 27
Description: Although pulmonary vascular bed has been the main subject of research for many years in pulmonary hypertension (PH), interest has recently started to divert towards the possibility of a co-existing peripheral microangiopathy. The aim of the current study was to investigate the presence of nailfold video-capillaroscopic (NVC) structural changes in patients with precapillary PH and to identify possible associations of NVC measurements with markers of disease severity. Α prospective case-control study was performed in 28 consecutive patients with precapillary PH [14 with idiopathic pulmonary arterial hypertension (IPAH) and 14 with chronic thromboembolic pulmonary hypertension (CTEPH)] and 30 healthy controls. NVC quantitative and qualitative parameters were evaluated using Optilia Digital Capillaroscope. To ensure inter-observer repeatability capillaroscopic images were reviewed by two independent investigators. For multiple comparisons among continuous variables, one-way ANOVA or the Kruskal-Wallis test were used. Differences between the groups were tested with post-hoc analysis with adjustment for multiple comparisons (Bonferroni test). Both IPAH (71.4% were women, mean age 53.1 ± 13.4 years) and CTEPH (64.3% women, mean age 60.9 ± 14.4 years) groups presented reduced capillary density compared to healthy controls (8.4 ± 1.2 loops/mm and 8.0 ± 1.2 loops/mm vs. 9.7 ± 0.81 loops/mm, p < 0.001) and increased loop width (15.7 ± 3.9 μm and 15.8 ± 1.9 μm vs. 11.5 ± 2.3 μm, p < 0.001). More than half of patients with IPAH presented microhaemorrhages on capillary nailfold, while increased shape abnormalities in capillary morphology and more capillary thrombi per linear mm were detected in patients with CTEPH compared to patients with IPAH and healthy controls. All PH patients presented a non-specific NVC pattern compared to controls (p < 0.001). The findings of the study reveal a degree of significant peripheral microvascular alterations in patients with IPAH and CTEPH, suggesting a generalized impairment of peripheral microvasculature in pulmonary vascular disease.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1465-993X
ISSN: 1465-9921
EISSN: 1465-993X
DOI: 10.1186/s12931-021-01622-1
PMID: 33478514
Source: GFMER Free Medical Journals
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Peripheral microangiopathy in precapillary pulmonary hypertension: a nailfold video capillaroscopy prospective study

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