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Genomic Characteristics of Stx2e-Producing Escherichia coli Strains Derived from Humans, Animals, and Meats

Pathogens (Basel), 2021-11, Vol.10 (12), p.1551 [Peer Reviewed Journal]

2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;info:eu-repo/semantics/openAccess ;2021 by the authors. 2021 ;ISSN: 2076-0817 ;EISSN: 2076-0817 ;DOI: 10.3390/pathogens10121551 ;PMID: 34959506

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  • Title:
    Genomic Characteristics of Stx2e-Producing Escherichia coli Strains Derived from Humans, Animals, and Meats
  • Author: Yang, Xi ; Wu, Yannong ; Liu, Qian ; Sun, Hui ; Luo, Ming ; Xiong, Yanwen ; Matussek, Andreas ; Hu, Bin ; Bai, Xiangning
  • Subjects: Animals ; Azithromycin ; Beef ; E coli ; Edema ; Escherichia coli ; Food ; Food sources ; Gene sequencing ; Genes ; Genomes ; Health risks ; Heat-labile enterotoxin ; Hogs ; Infections ; Meat ; Medicin och hälsovetenskap ; Multidrug resistance ; Pathogens ; Phylogenetics ; Phylogeny ; Serotypes ; Shiga toxin ; Stx2e ; Thermal stability ; Toxins ; Virulence ; Whole genome sequencing
  • Is Part Of: Pathogens (Basel), 2021-11, Vol.10 (12), p.1551
  • Description: Shiga toxin (Stx) can be classified into two types, Stx1 and Stx2, and different subtypes. Stx2e is a subtype commonly causing porcine edema disease and rarely reported in humans. The purpose of this study was to analyze the prevalence and genetic characteristics of Stx2e-producing (Stx2e-STEC) strains from humans compared to strains from animals and meats in China. Stx2e-STEC strains were screened from our STEC collection, and whole-genome sequencing was performed to characterize their genetic features. Our study showed a wide distribution of Stx2e-STEC among diverse hosts and a higher proportion of Stx2e-STEC among human STEC strains in China. Three human Stx2e-STEC isolates belonged to O100:H30, Onovel26:H30, and O8:H9 serotypes and varied in genetic features. Human Stx2e-STECs phylogenetically clustered with animal- and food-derived strains. Stx2e-STEC strains from animals and meat showed multidrug resistance, while human strains were only resistant to azithromycin and tetracycline. Of note, a high proportion (55.9%) of Stx2e-STEC strains, including one human strain, carried the heat-stable and heat-labile enterotoxin-encoding genes and , exhibiting a STEC/enterotoxigenic (ETEC) hybrid pathotype. Given that no distinct genetic feature was found in Stx2e-STEC strains from different sources, animal- and food-derived strains may pose the risk of causing human disease.
  • Publisher: Switzerland: MDPI AG
  • Language: English;Norwegian
  • Identifier: ISSN: 2076-0817
    EISSN: 2076-0817
    DOI: 10.3390/pathogens10121551
    PMID: 34959506
  • Source: NORA Norwegian Open Research Archives
    PubMed Central
    SWEPUB Freely available online
    ROAD: Directory of Open Access Scholarly Resources
    ProQuest Central
    DOAJ Directory of Open Access Journals
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