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Epidemiological characteristics of nosocomial diarrhea caused by Clostridium difficile in a tertiary level hospital in Serbia

Srpski arhiv za celokupno lekarstvo, 2013-07, Vol.141 (7-8), p.482-489

ISSN: 0370-8179 ;EISSN: 2406-0895 ;DOI: 10.2298/SARH1308482S ;PMID: 24073554

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Title:
Epidemiological characteristics of nosocomial diarrhea caused by Clostridium difficile in a tertiary level hospital in Serbia
Author: Suljagic, Vesna ; Djordjevic, Dragan ; Lazic, Srdjan ; Mijovic, Biljana
Subjects: Anti-Bacterial Agents - therapeutic use ; Case-Control Studies ; Clostridium difficile ; Clostridium difficile associated disease (CDAD) ; Cross Infection - drug therapy ; Cross Infection - epidemiology ; Cross Infection - microbiology ; Diarrhea - drug therapy ; Diarrhea - epidemiology ; Diarrhea - microbiology ; Enterocolitis, Pseudomembranous - drug therapy ; Enterocolitis, Pseudomembranous - epidemiology ; Enterocolitis, Pseudomembranous - microbiology ; epidemiology ; Humans ; Incidence ; prevention and control ; risk factor ; Risk Factors ; Serbia - epidemiology
Is Part Of: Srpski arhiv za celokupno lekarstvo, 2013-07, Vol.141 (7-8), p.482-489
Description: Among the most important causes of diarrhea in modern hospitals is Clostridium difficile (C. difficile). A wide spectrum of diseases caused by this bacterium is now known as C. difficile associated disease (CDAD). The development of CDAD is usually preceded by the administration of antimicrobial therapy and fecal-oral infections with C. difficile. Over the last years epidemiology of CDAD has significantly changed. Recently, a hypervirulent BI/NAP1/027 strain, the cause of severe epidemics in North America and Western Europe, has been identified. The aim of this study was to identify risk factors for CDAD in patients operated on at the Military Medical Academy (MMA). The study included all patients who underwent surgery at the MMA during 2010. Nested case-control study design was used. The subjects were divided into groups of operated patients with and without CDAD. The patients were under prospective follow-up, while their data were collected using a questionnaire during a routine epidemiological control. During 2010 the incidence rate of CDAD was 3.3 per 10,000 hospital days. Univariate regression analysis showed that the length of administration of one or two antibiotics, as well as concurrent administration of two antibiotics, were far more frequently observed in the patients with than in the patients without CDAD. Independent risk factor for the development of CDAD was the length of the administration of one antibiotic. Reduction in the incidence rate of CDAD can be achieved by using reliable measures of prevention and control; the rational use of antibiotics, early diagnosis and therapy of infected patients, contact isolation of infected persons, proper disinfection, and continued education of medical and nonmedical personnel.
Publisher: Serbia: Serbian Medical Society
Language: Serbian;English
Identifier: ISSN: 0370-8179
EISSN: 2406-0895
DOI: 10.2298/SARH1308482S
PMID: 24073554
Source: MEDLINE
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Epidemiological characteristics of nosocomial diarrhea caused by Clostridium difficile in a tertiary level hospital in Serbia

ISSN: 0370-8179 ;EISSN: 2406-0895 ;DOI: 10.2298/SARH1308482S ;PMID: 24073554

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