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06.01 THE INFLUENCE OF CARDIOVASCULAR DISEASE AND RISK FACTORS ON AGE-RELATED CHANGES IN AORTIC PULSE WAVE VELOCITY

Artery research, 2007-09, Vol.1 (2), p.49-50 [Peer Reviewed Journal]

Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2007. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 1876-4401 ;ISSN: 1872-9312 ;EISSN: 1876-4401 ;DOI: 10.1016/j.artres.2007.07.046

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  • Title:
    06.01 THE INFLUENCE OF CARDIOVASCULAR DISEASE AND RISK FACTORS ON AGE-RELATED CHANGES IN AORTIC PULSE WAVE VELOCITY
  • Author: McEniery, C.M. ; Yasmin, Y. ; Munnery, M. ; Wallace, S.M.L. ; McDonnell, B. ; Maki-Petaja, K.M. ; Hickson, S. ; Cockcroft, J.R. ; Wilkinson, I.B.
  • Subjects: Age ; Cardiovascular disease ; Diabetes ; Hypertension ; Risk factors
  • Is Part Of: Artery research, 2007-09, Vol.1 (2), p.49-50
  • Description: We have demonstrated previously that age-related changes in aortic pulse wave velocity (PWV) are more prominent in individuals over the age of 50 years, suggesting that aortic PWV might provide a sensitive marker of risk in older subjects. Therefore, the aim of this investigation was to assess the impact of cardiovascular disease and risk factors on age-related changes in aortic PWV.Data from 4219 participants in the ACCT Study† cohort were analysed (aged 18-92 years). In all subjects, seated and supine brachial BP was measured following at least 10 minutes of rest. Central (aortic) BP was derived by pulse wave analysis, and aortic (carotid-femoral) and brachial PWV were recorded (SphygmoCor). Subjects were then divided into groups based on the presence of cardiovascular disease (n = 445) or risk factors: diabetes (n = 311), hypertension (n = 952), hypercholesterolaemia (n = 196) and smoking (n = 318), leaving 1997 control subjects, all of whom were free of cardiovascular risk factors and medication. Peripheral and central blood pressure and aortic PWV all increased significantly with age (P<0.001). However, compared with healthy controls, there was a steeper age-related rise in aortic PWV after the age of 50 years in subjects with cardiovascular disease or risk factors (P<0.001, Figure), even after adjusting for differences in mean pressure. In multivariate analyses, hypertension, diabetes, smoking and the presence of cardiovascular disease were independently associated with aortic PWV (R2 = 0.65, P<0.001). In conclusion, aortic PWV appears to be a sensitive marker of cardiovascular risk in individuals aged over 50 years.
  • Publisher: Cardiff: Springer Nature B.V
  • Language: English
  • Identifier: ISSN: 1876-4401
    ISSN: 1872-9312
    EISSN: 1876-4401
    DOI: 10.1016/j.artres.2007.07.046
  • Source: Directory of Open Access Journals
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