Language:

Microcirculation in obesity: an unexplored domain

Anais da Academia Brasileira de Ciências, 2007-12, Vol.79 (4), p.617-638 [Peer Reviewed Journal]

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. ;ISSN: 0001-3765 ;ISSN: 1678-2690 ;EISSN: 1678-2690 ;DOI: 10.1590/s0001-37652007000400005 ;PMID: 18066432

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Microcirculation in obesity: an unexplored domain
Author: Wiernsperger, Nicolas ; Nivoit, Pierre ; Bouskela, Eliete
Subjects: Animals ; birth weight ; cardiovascular disease ; Cardiovascular Diseases - etiology ; diabetes mellitus ; Diabetes Mellitus - etiology ; doença cardiovascular ; Endothelium, Vascular - physiopathology ; Humans ; Intra-Abdominal Fat - metabolism ; Intra-Abdominal Fat - physiopathology ; leptin ; leptina ; metabolic syndrome ; Microcirculation - metabolism ; Microcirculation - physiopathology ; MULTIDISCIPLINARY SCIENCES ; Obesity - genetics ; Obesity - metabolism ; Obesity - physiopathology ; peso ao nascer ; Risk Factors ; síndrome metabólica ; Vasoconstriction ; Vasodilation
Is Part Of: Anais da Academia Brasileira de Ciências, 2007-12, Vol.79 (4), p.617-638
Description: Obesity is traditionally linked to diabetes and cardiovascular diseases. Very recent experimental, clinical and epidemiological, sometimes provocative, data challenge this automaticity by showing that not the amount but the distribution of fat is the important determinant. Moderate abdominal fat accumulation may thus be more harmful than even consequent overweight. In view of the worldwide burden of obesity, factors leading to it in children and young adults must urgently be identified. Since obesity is a very complex cardiometabolic situation, this will require to focus investigations on uncomplicated obese subjects and adequate animal models. The recent discovery of intergenerational transmissions of obesity risk factors and also the key role played by gestational and perinatal events (epigenetic factors) give rise to completely new concepts and research avenues. Considering the potential close relationship between microcirculation and tissue metabolism, demonstrations of structural and/or functional abnormalities in microvascular physiology very early in life of subjects at risk for obesity might provide a solid basis for further investigations of such links. Microcirculation(arterioles, capillaries and venules) is conceivably a key compartment determining over one or several decades the translation of genetic and epigenetic factors into fat accumulation. Available animal models should serve to answer this cardinal question.
Publisher: Brazil: Academia Brasileira de Ciências
Language: English;Portuguese
Identifier: ISSN: 0001-3765
ISSN: 1678-2690
EISSN: 1678-2690
DOI: 10.1590/s0001-37652007000400005
PMID: 18066432
Source: IngentaConnect Free/Open Access Journals
SciELO
GFMER Free Medical Journals
MEDLINE
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Microcirculation in obesity: an unexplored domain

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. ;ISSN: 0001-3765 ;ISSN: 1678-2690 ;EISSN: 1678-2690 ;DOI: 10.1590/s0001-37652007000400005 ;PMID: 18066432

Searching Remote Databases, Please Wait