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Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases

Molecules, 2015-03, Vol.20 (3), p.4655-4680 [Peer Reviewed Journal]

Copyright MDPI AG 2015 ;info:eu-repo/semantics/openAccess © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). http://creativecommons.org/licenses/by/4.0/ ;2015 by the authors. 2015 ;ISSN: 1420-3049 ;EISSN: 1420-3049 ;DOI: 10.3390/molecules20034655 ;PMID: 25781069

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Title:
Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases
Author: Rodríguez-Morató, Jose ; Xicota, Laura ; Fitó, Montse ; Farré, Magí ; Dierssen, Mara ; de la Torre, Rafael
Subjects: Animals ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - pharmacokinetics ; Anti-Inflammatory Agents - therapeutic use ; Antioxidants - chemistry ; Antioxidants - pharmacokinetics ; Antioxidants - therapeutic use ; Aspectes genètics ; Biological Availability ; Degeneració ; Diet, Mediterranean ; Efectes fisiològics ; Fenols ; Humans ; Hydroxytyrosol ; In Vitro Techniques ; Neurodegenerative diseases ; Neurodegenerative Diseases - drug therapy ; Neuroprotective agents ; Nutrició ; Oli d'oliva ; Olive oil ; Olive Oil - chemistry ; Phenolic compounds ; Phenylethyl Alcohol - analogs & derivatives ; Phenylethyl Alcohol - chemistry ; Phenylethyl Alcohol - pharmacokinetics ; Phenylethyl Alcohol - therapeutic use ; Prevention ; Review ; Sistema nerviós ; Tyrosol ; Ús terapèutic
Is Part Of: Molecules, 2015-03, Vol.20 (3), p.4655-4680
Description: Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of neurodegenerative diseases and better cognitive performance. Virgin olive oil, the main source of lipids in the MD, is rich in minor phenolic components, particularly hydroxytyrosol (HT). HT potent antioxidant and anti-inflammatory actions have attracted researchers' attention and may contribute to neuroprotective effects credited to MD. In this review HT bioavailability and pharmacokinetics are presented prior to discussing health beneficial effects. In vitro and in vivo neuroprotective effects together with its multiple mechanisms of action are reviewed. Other microconstituents of olive oil are also considered due to their potential neuroprotective effects (oleocanthal, triterpenic acids). Finally, we discuss the potential role of HT as a therapeutic tool in the prevention of neurodegenerative diseases.
Publisher: Switzerland: MDPI AG
Language: English;Catalan
Identifier: ISSN: 1420-3049
EISSN: 1420-3049
DOI: 10.3390/molecules20034655
PMID: 25781069
Source: Recercat
GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection
ProQuest Central
DOAJ Directory of Open Access Journals

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Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases

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