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Effects of statins on mitochondrial pathways

Journal of cachexia, sarcopenia and muscle, 2021-04, Vol.12 (2), p.237-251 [Peer Reviewed Journal]

2021 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders ;2021 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders. ;2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 2190-5991 ;EISSN: 2190-6009 ;DOI: 10.1002/jcsm.12654 ;PMID: 33511728

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  • Title:
    Effects of statins on mitochondrial pathways
  • Author: Mollazadeh, Hamid ; Tavana, Erfan ; Fanni, Giovanni ; Bo, Simona ; Banach, Maciej ; Pirro, Matteo ; Haehling, Stephan ; Jamialahmadi, Tannaz ; Sahebkar, Amirhossein
  • Subjects: Apoptosis ; Cholesterol ; Coenzyme Q10 ; Cognitive impairment ; Cytochrome ; Diabetes ; Drug dosages ; Enzymes ; Kinases ; Laboratories ; Lipids ; Low density lipoprotein ; Metabolites ; Mitochondria ; Mortality ; Myopathy ; Oxidation ; Pain ; Phosphorylation ; Respiration ; Respiratory chain ; Review ; Reviews ; Rhabdomyolysis ; SAMS ; Statin ; Statins
  • Is Part Of: Journal of cachexia, sarcopenia and muscle, 2021-04, Vol.12 (2), p.237-251
  • Description: Statins are a family of drugs that are used for treating hyperlipidaemia with a recognized capacity to prevent cardiovascular disease events. They inhibit β‐hydroxy β‐methylglutaryl‐coenzyme A reductase, i.e. the rate‐limiting enzyme in mevalonate pathway, reduce endogenous cholesterol synthesis, and increase low‐density lipoprotein clearance by promoting low‐density lipoprotein receptor expression mainly in the hepatocytes. Statins have pleiotropic effects including stabilization of atherosclerotic plaques, immunomodulation, anti‐inflammatory properties, improvement of endothelial function, antioxidant, and anti‐thrombotic action. Despite all beneficial effects, statins may elicit adverse reactions such as myopathy. Studies have shown that mitochondria play an important role in statin‐induced myopathies. In this review, we aim to report the mechanisms of action of statins on mitochondrial function. Results have shown that statins have several effects on mitochondria including reduction of coenzyme Q10 level, inhibition of respiratory chain complexes, induction of mitochondrial apoptosis, dysregulation of Ca2+ metabolism, and carnitine palmitoyltransferase‐2 expression. The use of statins has been associated with the onset of additional pathological conditions like diabetes and dementia as a result of interference with mitochondrial pathways by various mechanisms, such as reduction in mitochondrial oxidative phosphorylation, increase in oxidative stress, decrease in uncoupling protein 3 concentration, and interference in amyloid‐β metabolism. Overall, data reported in this review suggest that statins may have major effects on mitochondrial function, and some of their adverse effects might be mediated through mitochondrial pathways.
  • Publisher: Germany: John Wiley & Sons, Inc
  • Language: English
  • Identifier: ISSN: 2190-5991
    EISSN: 2190-6009
    DOI: 10.1002/jcsm.12654
    PMID: 33511728
  • Source: Open Access: Wiley Blackwell Open Access Journals
    Geneva Foundation Free Medical Journals at publisher websites
    AUTh Library subscriptions: ProQuest Central
    PubMed Central
    DOAJ Directory of Open Access Journals
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